Bridging spinal cord injuries

One strategy for spinal cord injury repair is to make cellular bridges that support axon regeneration. However, the bridging cells often fail to integrate with host tissue and may lead to increased pain sensitivity. Recent work has tested bridging with two forms of progenitor-derived astrocyte. One...

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Detalles Bibliográficos
Autor principal: Fawcett, James W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776407/
https://www.ncbi.nlm.nih.gov/pubmed/18947368
http://dx.doi.org/10.1186/jbiol89
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author Fawcett, James W
author_facet Fawcett, James W
author_sort Fawcett, James W
collection PubMed
description One strategy for spinal cord injury repair is to make cellular bridges that support axon regeneration. However, the bridging cells often fail to integrate with host tissue and may lead to increased pain sensitivity. Recent work has tested bridging with two forms of progenitor-derived astrocyte. One type integrates, suppresses scar formation and promotes axon regeneration, whereas another very similar type, reported in Journal of Biology, does not support regeneration and increases pain sensitivity.
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spelling pubmed-27764072009-11-13 Bridging spinal cord injuries Fawcett, James W J Biol Minireview One strategy for spinal cord injury repair is to make cellular bridges that support axon regeneration. However, the bridging cells often fail to integrate with host tissue and may lead to increased pain sensitivity. Recent work has tested bridging with two forms of progenitor-derived astrocyte. One type integrates, suppresses scar formation and promotes axon regeneration, whereas another very similar type, reported in Journal of Biology, does not support regeneration and increases pain sensitivity. BioMed Central 2008 2008-10-15 /pmc/articles/PMC2776407/ /pubmed/18947368 http://dx.doi.org/10.1186/jbiol89 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Minireview
Fawcett, James W
Bridging spinal cord injuries
title Bridging spinal cord injuries
title_full Bridging spinal cord injuries
title_fullStr Bridging spinal cord injuries
title_full_unstemmed Bridging spinal cord injuries
title_short Bridging spinal cord injuries
title_sort bridging spinal cord injuries
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776407/
https://www.ncbi.nlm.nih.gov/pubmed/18947368
http://dx.doi.org/10.1186/jbiol89
work_keys_str_mv AT fawcettjamesw bridgingspinalcordinjuries

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