HIV- 1 Protease Inhibits Cap- and Poly(A)-Dependent Translation upon eIF4GI and PABP Cleavage

A number of viral proteases are able to cleave translation initiation factors leading to the inhibition of cellular translation. This is the case of human immunodeficiency virus type 1 protease (HIV-1 PR), which hydrolyzes eIF4GI and poly(A)-binding protein (PABP). Here, the effect of HIV-1 PR on ce...

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Detalles Bibliográficos
Autores principales: Castelló, Alfredo, Franco, David, Moral-López, Pablo, Berlanga, Juan J., Álvarez, Enrique, Wimmer, Eckard, Carrasco, Luis
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776998/
https://www.ncbi.nlm.nih.gov/pubmed/19956697
http://dx.doi.org/10.1371/journal.pone.0007997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776998/
https://www.ncbi.nlm.nih.gov/pubmed/19956697
http://dx.doi.org/10.1371/journal.pone.0007997

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