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Machine learning integration for predicting the effect of single amino acid substitutions on protein stability

BACKGROUND: Computational prediction of protein stability change due to single-site amino acid substitutions is of interest in protein design and analysis. We consider the following four ways to improve the performance of the currently available predictors: (1) We include additional sequence- and st...

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Detalles Bibliográficos
Autores principales:	Özen, Ayşegül, Gönen, Mehmet, Alpaydın, Ethem, Haliloğlu, Türkan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777163/ https://www.ncbi.nlm.nih.gov/pubmed/19840377 http://dx.doi.org/10.1186/1472-6807-9-66

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