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Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation

The infectious agent in prion diseases consists of an aberrantly folded isoform of the cellular prion protein (PrP(c)), termed PrP(Sc), which accumulates in brains of affected individuals. Studies on prion-infected cultured cells indicate that cellular cholesterol homeostasis influences PrP(Sc) prop...

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Detalles Bibliográficos
Autores principales:	Gilch, Sabine, Bach, Christian, Lutzny, Gloria, Vorberg, Ina, Schätzl, Hermann M.
Formato:	Texto
Lenguaje:	English
Publicado:	SP Birkhäuser Verlag Basel 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777232/ https://www.ncbi.nlm.nih.gov/pubmed/19823766 http://dx.doi.org/10.1007/s00018-009-0158-4

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