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GD3 Synthase Overexpression Sensitizes Hepatocarcinoma Cells to Hypoxia and Reduces Tumor Growth by Suppressing the cSrc/NF-κB Survival Pathway

BACKGROUND: Hypoxia-mediated HIF-1α stabilization and NF-κB activation play a key role in carcinogenesis by fostering cancer cell survival, angiogenesis and tumor invasion. Gangliosides are integral components of biological membranes with an increasingly recognized role as signaling intermediates. I...

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Detalles Bibliográficos
Autores principales:	Lluis, Josep M., Llacuna, Laura, von Montfort, Claudia, Bárcena, Cristina, Enrich, Carlos, Morales, Albert, Fernandez-Checa, José C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777380/ https://www.ncbi.nlm.nih.gov/pubmed/19956670 http://dx.doi.org/10.1371/journal.pone.0008059

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