Cargando…
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis
Objective. IL-23 is a pro-inflammatory cytokine proposed to be central to the development of autoimmune disease. We investigated whether IL-23, together with the downstream mediator IL-17A, was present and functional in RA in humans. Methods. RA synovial cells were cultured in the presence or absenc...
Autores principales: | Hillyer, Philippa, Larché, Maggie J., Bowman, Edward P., McClanahan, Terrill K., de Waal Malefyt, Rene, Schewitz, Lauren P., Giddins, Grey, Feldmann, Marc, Kastelein, Robert A., Brennan, Fionula M. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777488/ https://www.ncbi.nlm.nih.gov/pubmed/19815670 http://dx.doi.org/10.1093/rheumatology/kep293 |
Ejemplares similares
-
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis
por: Chan, Jason R., et al.
Publicado: (2006) -
Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease
por: Cayatte, Corinne, et al.
Publicado: (2012) -
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
por: Boniface, Katia, et al.
Publicado: (2009) -
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
por: Kleinschek, Melanie A., et al.
Publicado: (2009) -
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
por: Murphy, Craig A., et al.
Publicado: (2003)