CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis

BACKGROUND: CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for inflammatory disease. METHODS: Here we examined the effects of CCR2 blockade with a potent small molecule antagonist to determine the pharma...

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Detalles Bibliográficos
Autores principales: Wang, Yuanfan, Cui, Long, Gonsiorek, Waldemar, Min, Soo-Hong, Anilkumar, Gopinadhan, Rosenblum, Stuart, Kozlowski, Joseph, Lundell, Daniel, Fine, Jay S, Grant, Ethan P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777898/
https://www.ncbi.nlm.nih.gov/pubmed/19906300
http://dx.doi.org/10.1186/1476-9255-6-32

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