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Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review
We report a case of a perinatally HIV-infected patient aged 9 years, who presented with right-sided hemiplegia. His initial CD4 T-cell was of 0.21% (4 cells/μL) and plasma HIV RNA virus of 185 976 copies/mL (log 5.27). Plasma and CSF samples were subsequently positive for JCV. Twelve days after the...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778135/ https://www.ncbi.nlm.nih.gov/pubmed/20041004 http://dx.doi.org/10.1155/2009/348507 |
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author | Oberdorfer, Peninnah Washington, Charles H. Katanyuwong, Kamornwan Jittamala, Podjanee |
author_facet | Oberdorfer, Peninnah Washington, Charles H. Katanyuwong, Kamornwan Jittamala, Podjanee |
author_sort | Oberdorfer, Peninnah |
collection | PubMed |
description | We report a case of a perinatally HIV-infected patient aged 9 years, who presented with right-sided hemiplegia. His initial CD4 T-cell was of 0.21% (4 cells/μL) and plasma HIV RNA virus of 185 976 copies/mL (log 5.27). Plasma and CSF samples were subsequently positive for JCV. Twelve days after the initiation of highly active antiretroviral therapy (HAART), the MRI showed progressive white matter lesions with asymmetrical deep and subcortical white matter lesions over the left frontotemporoparietal region and the right frontal lobe. Immune Reconstitution Inflammatory Syndrome (IRIS) was suspected, and the patient was treated with methylprednisolone. His clinical symptoms worsened and despite therapy the patient deteriorated. |
format | Text |
id | pubmed-2778135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27781352009-12-29 Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review Oberdorfer, Peninnah Washington, Charles H. Katanyuwong, Kamornwan Jittamala, Podjanee Int J Pediatr Case Report We report a case of a perinatally HIV-infected patient aged 9 years, who presented with right-sided hemiplegia. His initial CD4 T-cell was of 0.21% (4 cells/μL) and plasma HIV RNA virus of 185 976 copies/mL (log 5.27). Plasma and CSF samples were subsequently positive for JCV. Twelve days after the initiation of highly active antiretroviral therapy (HAART), the MRI showed progressive white matter lesions with asymmetrical deep and subcortical white matter lesions over the left frontotemporoparietal region and the right frontal lobe. Immune Reconstitution Inflammatory Syndrome (IRIS) was suspected, and the patient was treated with methylprednisolone. His clinical symptoms worsened and despite therapy the patient deteriorated. Hindawi Publishing Corporation 2009 2009-09-16 /pmc/articles/PMC2778135/ /pubmed/20041004 http://dx.doi.org/10.1155/2009/348507 Text en Copyright © 2009 Peninnah Oberdorfer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Oberdorfer, Peninnah Washington, Charles H. Katanyuwong, Kamornwan Jittamala, Podjanee Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
title | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
title_full | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
title_fullStr | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
title_full_unstemmed | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
title_short | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
title_sort | progressive multifocal leukoencephalopathy in hiv-infected children: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778135/ https://www.ncbi.nlm.nih.gov/pubmed/20041004 http://dx.doi.org/10.1155/2009/348507 |
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