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Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children

Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation...

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Autores principales: Kikuta, Hideaki, Shibata, Mutsuo, Nakata, Shuji, Yamanaka, Tatsuru, Sakata, Hiroshi, Akizawa, Kouji, Kobayashi, Kunihiko
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778142/
https://www.ncbi.nlm.nih.gov/pubmed/20041005
http://dx.doi.org/10.1155/2009/863608
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author Kikuta, Hideaki
Shibata, Mutsuo
Nakata, Shuji
Yamanaka, Tatsuru
Sakata, Hiroshi
Akizawa, Kouji
Kobayashi, Kunihiko
author_facet Kikuta, Hideaki
Shibata, Mutsuo
Nakata, Shuji
Yamanaka, Tatsuru
Sakata, Hiroshi
Akizawa, Kouji
Kobayashi, Kunihiko
author_sort Kikuta, Hideaki
collection PubMed
description Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation of therapy) occurred in 7 of the 77 children in the 5-day treatment group and in 1 of the 149 children in the 10-day treatment group; the incidence of recurrence being significantly higher in the 5-day treatment group. Bacteriologic treatment failure (GABHS isolation without overt pharyngitis) at follow-up culture was observed in 7 of the 77 children in the 5-day treatment group and 17 of the 149 children in the 10-day treatment group. There was no statistical difference between the two groups. A 5-day course of oral cephalosporins is not always recommended for treatment of GABHS pharyngitis in children who have repeated episodes of pharyngitis.
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spelling pubmed-27781422009-12-29 Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children Kikuta, Hideaki Shibata, Mutsuo Nakata, Shuji Yamanaka, Tatsuru Sakata, Hiroshi Akizawa, Kouji Kobayashi, Kunihiko Int J Pediatr Clinical Study Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation of therapy) occurred in 7 of the 77 children in the 5-day treatment group and in 1 of the 149 children in the 10-day treatment group; the incidence of recurrence being significantly higher in the 5-day treatment group. Bacteriologic treatment failure (GABHS isolation without overt pharyngitis) at follow-up culture was observed in 7 of the 77 children in the 5-day treatment group and 17 of the 149 children in the 10-day treatment group. There was no statistical difference between the two groups. A 5-day course of oral cephalosporins is not always recommended for treatment of GABHS pharyngitis in children who have repeated episodes of pharyngitis. Hindawi Publishing Corporation 2009 2009-03-05 /pmc/articles/PMC2778142/ /pubmed/20041005 http://dx.doi.org/10.1155/2009/863608 Text en Copyright © 2009 Hideaki Kikuta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Kikuta, Hideaki
Shibata, Mutsuo
Nakata, Shuji
Yamanaka, Tatsuru
Sakata, Hiroshi
Akizawa, Kouji
Kobayashi, Kunihiko
Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children
title Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children
title_full Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children
title_fullStr Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children
title_full_unstemmed Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children
title_short Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children
title_sort comparative study of 5-day and 10-day cefditoren pivoxil treatments for recurrent group a β-hemolytic streptococcus pharyngitis in children
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778142/
https://www.ncbi.nlm.nih.gov/pubmed/20041005
http://dx.doi.org/10.1155/2009/863608
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