Cargando…
Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children
Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778142/ https://www.ncbi.nlm.nih.gov/pubmed/20041005 http://dx.doi.org/10.1155/2009/863608 |
_version_ | 1782174224971988992 |
---|---|
author | Kikuta, Hideaki Shibata, Mutsuo Nakata, Shuji Yamanaka, Tatsuru Sakata, Hiroshi Akizawa, Kouji Kobayashi, Kunihiko |
author_facet | Kikuta, Hideaki Shibata, Mutsuo Nakata, Shuji Yamanaka, Tatsuru Sakata, Hiroshi Akizawa, Kouji Kobayashi, Kunihiko |
author_sort | Kikuta, Hideaki |
collection | PubMed |
description | Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation of therapy) occurred in 7 of the 77 children in the 5-day treatment group and in 1 of the 149 children in the 10-day treatment group; the incidence of recurrence being significantly higher in the 5-day treatment group. Bacteriologic treatment failure (GABHS isolation without overt pharyngitis) at follow-up culture was observed in 7 of the 77 children in the 5-day treatment group and 17 of the 149 children in the 10-day treatment group. There was no statistical difference between the two groups. A 5-day course of oral cephalosporins is not always recommended for treatment of GABHS pharyngitis in children who have repeated episodes of pharyngitis. |
format | Text |
id | pubmed-2778142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27781422009-12-29 Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children Kikuta, Hideaki Shibata, Mutsuo Nakata, Shuji Yamanaka, Tatsuru Sakata, Hiroshi Akizawa, Kouji Kobayashi, Kunihiko Int J Pediatr Clinical Study Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation of therapy) occurred in 7 of the 77 children in the 5-day treatment group and in 1 of the 149 children in the 10-day treatment group; the incidence of recurrence being significantly higher in the 5-day treatment group. Bacteriologic treatment failure (GABHS isolation without overt pharyngitis) at follow-up culture was observed in 7 of the 77 children in the 5-day treatment group and 17 of the 149 children in the 10-day treatment group. There was no statistical difference between the two groups. A 5-day course of oral cephalosporins is not always recommended for treatment of GABHS pharyngitis in children who have repeated episodes of pharyngitis. Hindawi Publishing Corporation 2009 2009-03-05 /pmc/articles/PMC2778142/ /pubmed/20041005 http://dx.doi.org/10.1155/2009/863608 Text en Copyright © 2009 Hideaki Kikuta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Kikuta, Hideaki Shibata, Mutsuo Nakata, Shuji Yamanaka, Tatsuru Sakata, Hiroshi Akizawa, Kouji Kobayashi, Kunihiko Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
title | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
title_full | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
title_fullStr | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
title_full_unstemmed | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
title_short | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
title_sort | comparative study of 5-day and 10-day cefditoren pivoxil treatments for recurrent group a β-hemolytic streptococcus pharyngitis in children |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778142/ https://www.ncbi.nlm.nih.gov/pubmed/20041005 http://dx.doi.org/10.1155/2009/863608 |
work_keys_str_mv | AT kikutahideaki comparativestudyof5dayand10daycefditorenpivoxiltreatmentsforrecurrentgroupabhemolyticstreptococcuspharyngitisinchildren AT shibatamutsuo comparativestudyof5dayand10daycefditorenpivoxiltreatmentsforrecurrentgroupabhemolyticstreptococcuspharyngitisinchildren AT nakatashuji comparativestudyof5dayand10daycefditorenpivoxiltreatmentsforrecurrentgroupabhemolyticstreptococcuspharyngitisinchildren AT yamanakatatsuru comparativestudyof5dayand10daycefditorenpivoxiltreatmentsforrecurrentgroupabhemolyticstreptococcuspharyngitisinchildren AT sakatahiroshi comparativestudyof5dayand10daycefditorenpivoxiltreatmentsforrecurrentgroupabhemolyticstreptococcuspharyngitisinchildren AT akizawakouji comparativestudyof5dayand10daycefditorenpivoxiltreatmentsforrecurrentgroupabhemolyticstreptococcuspharyngitisinchildren AT kobayashikunihiko comparativestudyof5dayand10daycefditorenpivoxiltreatmentsforrecurrentgroupabhemolyticstreptococcuspharyngitisinchildren |