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Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
Erythrocyte measures are heritable and have important health implications, yet their genetic determinants are largely unknown. We performed genome-wide association analyses in 24,167 European-ancestry individuals for six erythrocyte traits and identified associations at 23 loci (P values 5×10(-8) to...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778265/ https://www.ncbi.nlm.nih.gov/pubmed/19862010 http://dx.doi.org/10.1038/ng.466 |
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| author | Ganesh, Santhi K. Zakai, Neil A. van Rooij, Frank J A. Soranzo, Nicole Smith, Albert V. Nalls, Michael A. Chen, Ming-Huei Kottgen, Anna Glazer, Nicole L. Dehghan, Abbas Kuhnel, Brigitte Aspelund, Thor Yang, Qiong Tanaka, Toshiko Jaffe, Andrew Bis, Joshua C M. Verwoert, Germaine C. Teumer, Alexander Fox, Caroline S. Guralnik, Jack M. Ehret, Georg B. Rice, Kenneth Felix, Janine F. Rendon, Augusto Eiriksdottir, Gudny Levy, Daniel Patel, Kushang V. Boerwinkle, Eric Rotter, Jerome I. Hofman, Albert Sambrook, Jennifer G. Hernandez, Dena Zheng, Gang Bandinelli, Stefania Singleton, Andrew B. Coresh, Josef Lumley, Thomas Uitterlinden, André G. vanGils, Janine M. Launer, Lenore J. Cupples, L. Adrienne Oostra, Ben A. Zwaginga, Jaap-Jan Ouwehand, Willem H. Thein, Swee-Lay Meisinger, Christa Deloukas, Panos Nauck, Matthias Spector, Tim Gieger, Christian Gudnason, Vilmundur van Duijn, Cornelia M. Psaty, Bruce M. Ferrucci, Luigi Chakravarti, Aravinda Greinacher, Andreas O’Donnell, Christopher J. Witteman, Jacqueline C M. Furth, Susan Cushman, Mary Harris, Tamara B. Lin, Jing-Ping |
| author_facet | Ganesh, Santhi K. Zakai, Neil A. van Rooij, Frank J A. Soranzo, Nicole Smith, Albert V. Nalls, Michael A. Chen, Ming-Huei Kottgen, Anna Glazer, Nicole L. Dehghan, Abbas Kuhnel, Brigitte Aspelund, Thor Yang, Qiong Tanaka, Toshiko Jaffe, Andrew Bis, Joshua C M. Verwoert, Germaine C. Teumer, Alexander Fox, Caroline S. Guralnik, Jack M. Ehret, Georg B. Rice, Kenneth Felix, Janine F. Rendon, Augusto Eiriksdottir, Gudny Levy, Daniel Patel, Kushang V. Boerwinkle, Eric Rotter, Jerome I. Hofman, Albert Sambrook, Jennifer G. Hernandez, Dena Zheng, Gang Bandinelli, Stefania Singleton, Andrew B. Coresh, Josef Lumley, Thomas Uitterlinden, André G. vanGils, Janine M. Launer, Lenore J. Cupples, L. Adrienne Oostra, Ben A. Zwaginga, Jaap-Jan Ouwehand, Willem H. Thein, Swee-Lay Meisinger, Christa Deloukas, Panos Nauck, Matthias Spector, Tim Gieger, Christian Gudnason, Vilmundur van Duijn, Cornelia M. Psaty, Bruce M. Ferrucci, Luigi Chakravarti, Aravinda Greinacher, Andreas O’Donnell, Christopher J. Witteman, Jacqueline C M. Furth, Susan Cushman, Mary Harris, Tamara B. Lin, Jing-Ping |
| author_sort | Ganesh, Santhi K. |
| collection | PubMed |
| description | Erythrocyte measures are heritable and have important health implications, yet their genetic determinants are largely unknown. We performed genome-wide association analyses in 24,167 European-ancestry individuals for six erythrocyte traits and identified associations at 23 loci (P values 5×10(-8) to 1×10(-57)). Replication testing in an independent set of 9,456 European-ancestry individuals showed strong evidence of association in all 23 loci in meta-analysis of the discovery and replication cohorts. Our findings include previously identified loci (HBS1L/MYB, HFE, TMPRSS6, TFR2, SPTA1) and novel associations (EPO, TFRC, SH2B3, and 15 other loci). This study has identified novel determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures. |
| format | Text |
| id | pubmed-2778265 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27782652010-05-01 Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium Ganesh, Santhi K. Zakai, Neil A. van Rooij, Frank J A. Soranzo, Nicole Smith, Albert V. Nalls, Michael A. Chen, Ming-Huei Kottgen, Anna Glazer, Nicole L. Dehghan, Abbas Kuhnel, Brigitte Aspelund, Thor Yang, Qiong Tanaka, Toshiko Jaffe, Andrew Bis, Joshua C M. Verwoert, Germaine C. Teumer, Alexander Fox, Caroline S. Guralnik, Jack M. Ehret, Georg B. Rice, Kenneth Felix, Janine F. Rendon, Augusto Eiriksdottir, Gudny Levy, Daniel Patel, Kushang V. Boerwinkle, Eric Rotter, Jerome I. Hofman, Albert Sambrook, Jennifer G. Hernandez, Dena Zheng, Gang Bandinelli, Stefania Singleton, Andrew B. Coresh, Josef Lumley, Thomas Uitterlinden, André G. vanGils, Janine M. Launer, Lenore J. Cupples, L. Adrienne Oostra, Ben A. Zwaginga, Jaap-Jan Ouwehand, Willem H. Thein, Swee-Lay Meisinger, Christa Deloukas, Panos Nauck, Matthias Spector, Tim Gieger, Christian Gudnason, Vilmundur van Duijn, Cornelia M. Psaty, Bruce M. Ferrucci, Luigi Chakravarti, Aravinda Greinacher, Andreas O’Donnell, Christopher J. Witteman, Jacqueline C M. Furth, Susan Cushman, Mary Harris, Tamara B. Lin, Jing-Ping Nat Genet Article Erythrocyte measures are heritable and have important health implications, yet their genetic determinants are largely unknown. We performed genome-wide association analyses in 24,167 European-ancestry individuals for six erythrocyte traits and identified associations at 23 loci (P values 5×10(-8) to 1×10(-57)). Replication testing in an independent set of 9,456 European-ancestry individuals showed strong evidence of association in all 23 loci in meta-analysis of the discovery and replication cohorts. Our findings include previously identified loci (HBS1L/MYB, HFE, TMPRSS6, TFR2, SPTA1) and novel associations (EPO, TFRC, SH2B3, and 15 other loci). This study has identified novel determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures. 2009-10-11 2009-11 /pmc/articles/PMC2778265/ /pubmed/19862010 http://dx.doi.org/10.1038/ng.466 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Ganesh, Santhi K. Zakai, Neil A. van Rooij, Frank J A. Soranzo, Nicole Smith, Albert V. Nalls, Michael A. Chen, Ming-Huei Kottgen, Anna Glazer, Nicole L. Dehghan, Abbas Kuhnel, Brigitte Aspelund, Thor Yang, Qiong Tanaka, Toshiko Jaffe, Andrew Bis, Joshua C M. Verwoert, Germaine C. Teumer, Alexander Fox, Caroline S. Guralnik, Jack M. Ehret, Georg B. Rice, Kenneth Felix, Janine F. Rendon, Augusto Eiriksdottir, Gudny Levy, Daniel Patel, Kushang V. Boerwinkle, Eric Rotter, Jerome I. Hofman, Albert Sambrook, Jennifer G. Hernandez, Dena Zheng, Gang Bandinelli, Stefania Singleton, Andrew B. Coresh, Josef Lumley, Thomas Uitterlinden, André G. vanGils, Janine M. Launer, Lenore J. Cupples, L. Adrienne Oostra, Ben A. Zwaginga, Jaap-Jan Ouwehand, Willem H. Thein, Swee-Lay Meisinger, Christa Deloukas, Panos Nauck, Matthias Spector, Tim Gieger, Christian Gudnason, Vilmundur van Duijn, Cornelia M. Psaty, Bruce M. Ferrucci, Luigi Chakravarti, Aravinda Greinacher, Andreas O’Donnell, Christopher J. Witteman, Jacqueline C M. Furth, Susan Cushman, Mary Harris, Tamara B. Lin, Jing-Ping Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium |
| title | Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium |
| title_full | Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium |
| title_fullStr | Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium |
| title_full_unstemmed | Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium |
| title_short | Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium |
| title_sort | multiple loci influence erythrocyte phenotypes in the charge consortium |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778265/ https://www.ncbi.nlm.nih.gov/pubmed/19862010 http://dx.doi.org/10.1038/ng.466 |
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