An NMR Study of the Bortezomib Degradation under Clinical Use Conditions

The (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl-boronic acid, bortezomib (BTZ), which binds the 20S proteasome subunit and causes a large inhibition of its activity, is a peptidomimetic boronic drug mainly used for the treatment of multiple myeloma. Commercial BTZ, stabi...

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Detalles Bibliográficos
Autores principales: Bolognese, Adele, Esposito, Anna, Manfra, Michele, Catalano, Lucio, Petruzziello, Fara, Martorelli, Maria Carmen, Pagliuca, Raffaella, Mazzarelli, Vittoria, Ottiero, Maria, Scalfaro, Melania, Rotoli, Bruno
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778348/
https://www.ncbi.nlm.nih.gov/pubmed/19960052
http://dx.doi.org/10.1155/2009/704928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778348/
https://www.ncbi.nlm.nih.gov/pubmed/19960052
http://dx.doi.org/10.1155/2009/704928

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