Single-Molecule Analysis of the Human Telomerase RNA·Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations

[Image: see text] It has been proposed that human telomerase RNA (hTR) interacts with dyskerin, prior to assembly of the telomerase holoenzyme. The direct interaction of dyskerin and hTR has not been demonstrated and is an experimentally challenging research problem because of difficulties in expres...

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Detalles Bibliográficos
Autores principales: Ashbridge, Beth, Orte, Angel, Yeoman, Justin A., Kirwan, Michael, Vulliamy, Tom, Dokal, Inderjeet, Klenerman, David, Balasubramanian, Shankar
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778356/
https://www.ncbi.nlm.nih.gov/pubmed/19835419
http://dx.doi.org/10.1021/bi901373e

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