Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P(2)

Mutations affecting the conversion of PI3P to the signaling lipid PI(3,5)P(2) result in spongiform degeneration of mouse brain and are associated with the human disorders Charcot–Marie–Tooth disease and amyotrophic lateral sclerosis (ALS). We now report accumulation of the proteins LC3-II, p62 and L...

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Detalles Bibliográficos
Autores principales: Ferguson, Cole J., Lenk, Guy M., Meisler, Miriam H.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778378/
https://www.ncbi.nlm.nih.gov/pubmed/19793721
http://dx.doi.org/10.1093/hmg/ddp460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778378/
https://www.ncbi.nlm.nih.gov/pubmed/19793721
http://dx.doi.org/10.1093/hmg/ddp460

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