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Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life

Rizatriptan is a 5HT (IB/ID) agonist with proven efficacy in the acute treatment of migraine headache. We performed a systematic review of the literature for clinical trials of rizatriptan incorporating important patient outcomes including consistency of response, preference, satisfaction, and quali...

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Detalles Bibliográficos
Autores principales: Amoozegar, Farnaz, Pringsheim, Tamara
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778411/
https://www.ncbi.nlm.nih.gov/pubmed/19936168
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author Amoozegar, Farnaz
Pringsheim, Tamara
author_facet Amoozegar, Farnaz
Pringsheim, Tamara
author_sort Amoozegar, Farnaz
collection PubMed
description Rizatriptan is a 5HT (IB/ID) agonist with proven efficacy in the acute treatment of migraine headache. We performed a systematic review of the literature for clinical trials of rizatriptan incorporating important patient outcomes including consistency of response, preference, satisfaction, and quality of life. We found evidence that rizatriptan provides consistent relief of migraine attacks and that patients prefer rizatriptan over other treatments because of its speed of relief. Patient satisfaction with rizatriptan is significantly higher than placebo, but appears equivalent to most other triptans. Migraine-specific quality of life at 24 hours is significantly better in patients treated with rizatriptan compared to placebo, while overall long-term quality of life is less affected. The published clinical trials included in this systematic review are subject to bias due to the open-label nature of preference trials and the doses chosen for comparison in head-to-head trials.
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spelling pubmed-27784112009-11-23 Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life Amoozegar, Farnaz Pringsheim, Tamara Patient Prefer Adherence Review Rizatriptan is a 5HT (IB/ID) agonist with proven efficacy in the acute treatment of migraine headache. We performed a systematic review of the literature for clinical trials of rizatriptan incorporating important patient outcomes including consistency of response, preference, satisfaction, and quality of life. We found evidence that rizatriptan provides consistent relief of migraine attacks and that patients prefer rizatriptan over other treatments because of its speed of relief. Patient satisfaction with rizatriptan is significantly higher than placebo, but appears equivalent to most other triptans. Migraine-specific quality of life at 24 hours is significantly better in patients treated with rizatriptan compared to placebo, while overall long-term quality of life is less affected. The published clinical trials included in this systematic review are subject to bias due to the open-label nature of preference trials and the doses chosen for comparison in head-to-head trials. Dove Medical Press 2009-11-03 /pmc/articles/PMC2778411/ /pubmed/19936168 Text en © 2009 Amoozegar and Pringsheim, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Amoozegar, Farnaz
Pringsheim, Tamara
Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life
title Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life
title_full Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life
title_fullStr Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life
title_full_unstemmed Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life
title_short Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life
title_sort rizatriptan for the acute treatment of migraine: consistency, preference, satisfaction, and quality of life
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778411/
https://www.ncbi.nlm.nih.gov/pubmed/19936168
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