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Drug-Induced Hematologic Syndromes

Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Metho...

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Autores principales: Mintzer, David M., Billet, Shira N., Chmielewski, Lauren
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778502/
https://www.ncbi.nlm.nih.gov/pubmed/19960059
http://dx.doi.org/10.1155/2009/495863
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author Mintzer, David M.
Billet, Shira N.
Chmielewski, Lauren
author_facet Mintzer, David M.
Billet, Shira N.
Chmielewski, Lauren
author_sort Mintzer, David M.
collection PubMed
description Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and reviews focus on individual drugs or cytopenias. Results. Drug-induced syndromes include hemolytic anemias, methemoglobinemia, red cell aplasia, sideroblastic anemia, megaloblastic anemia, polycythemia, aplastic anemia, leukocytosis, neutropenia, eosinophilia, immune thrombocytopenia, microangiopathic syndromes, hypercoagulability, hypoprothrombinemia, circulating anticoagulants, myelodysplasia, and acute leukemia. Some of the classic drugs known to cause hematologic abnormalities have been replaced by newer drugs, including biologics, accompanied by their own syndromes and unintended side effects. Conclusions. Drugs can induce toxicities spanning many hematologic syndromes, mediated by a variety of mechanisms. Physicians need to be alert to the potential for iatrogenic drug-induced hematologic complications.
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spelling pubmed-27785022009-12-03 Drug-Induced Hematologic Syndromes Mintzer, David M. Billet, Shira N. Chmielewski, Lauren Adv Hematol Review Article Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and reviews focus on individual drugs or cytopenias. Results. Drug-induced syndromes include hemolytic anemias, methemoglobinemia, red cell aplasia, sideroblastic anemia, megaloblastic anemia, polycythemia, aplastic anemia, leukocytosis, neutropenia, eosinophilia, immune thrombocytopenia, microangiopathic syndromes, hypercoagulability, hypoprothrombinemia, circulating anticoagulants, myelodysplasia, and acute leukemia. Some of the classic drugs known to cause hematologic abnormalities have been replaced by newer drugs, including biologics, accompanied by their own syndromes and unintended side effects. Conclusions. Drugs can induce toxicities spanning many hematologic syndromes, mediated by a variety of mechanisms. Physicians need to be alert to the potential for iatrogenic drug-induced hematologic complications. Hindawi Publishing Corporation 2009 2009-07-07 /pmc/articles/PMC2778502/ /pubmed/19960059 http://dx.doi.org/10.1155/2009/495863 Text en Copyright © 2009 David M. Mintzer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mintzer, David M.
Billet, Shira N.
Chmielewski, Lauren
Drug-Induced Hematologic Syndromes
title Drug-Induced Hematologic Syndromes
title_full Drug-Induced Hematologic Syndromes
title_fullStr Drug-Induced Hematologic Syndromes
title_full_unstemmed Drug-Induced Hematologic Syndromes
title_short Drug-Induced Hematologic Syndromes
title_sort drug-induced hematologic syndromes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778502/
https://www.ncbi.nlm.nih.gov/pubmed/19960059
http://dx.doi.org/10.1155/2009/495863
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