Inhibition of constitutive and cxc-chemokine-induced NF-κB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells

BACKGROUND: We determined how CXC-chemokine signalling and necrosis factor-κB (NF-κB) activity affected heat-shock protein 90 (Hsp90) inhibitor (geldanamycin (GA) and 17-allylamino-demethoxygeldanamycin (17-AAG)) cytotoxicity in castrate-resistant prostate cancer (CRPC). METHODS: Geldanamycin and 17...

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Detalles Bibliográficos
Autores principales: Seaton, A, Maxwell, P J, Hill, A, Gallagher, R, Pettigrew, J, Wilson, R H, Waugh, D J J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778515/
https://www.ncbi.nlm.nih.gov/pubmed/19809428
http://dx.doi.org/10.1038/sj.bjc.6605356

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