Preclinical mouse models for BRCA1-associated breast cancer

A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human B...

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Detalles Bibliográficos
Autores principales: Drost, R M, Jonkers, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778535/
https://www.ncbi.nlm.nih.gov/pubmed/19904273
http://dx.doi.org/10.1038/sj.bjc.6605350
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author Drost, R M
Jonkers, J
author_facet Drost, R M
Jonkers, J
author_sort Drost, R M
collection PubMed
description A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human BRCA1-related breast cancer and may therefore be useful for addressing clinically relevant questions.
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spelling pubmed-27785352010-11-17 Preclinical mouse models for BRCA1-associated breast cancer Drost, R M Jonkers, J Br J Cancer Minireview A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human BRCA1-related breast cancer and may therefore be useful for addressing clinically relevant questions. Nature Publishing Group 2009-11-17 2009-09-29 /pmc/articles/PMC2778535/ /pubmed/19904273 http://dx.doi.org/10.1038/sj.bjc.6605350 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Drost, R M
Jonkers, J
Preclinical mouse models for BRCA1-associated breast cancer
title Preclinical mouse models for BRCA1-associated breast cancer
title_full Preclinical mouse models for BRCA1-associated breast cancer
title_fullStr Preclinical mouse models for BRCA1-associated breast cancer
title_full_unstemmed Preclinical mouse models for BRCA1-associated breast cancer
title_short Preclinical mouse models for BRCA1-associated breast cancer
title_sort preclinical mouse models for brca1-associated breast cancer
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778535/
https://www.ncbi.nlm.nih.gov/pubmed/19904273
http://dx.doi.org/10.1038/sj.bjc.6605350
work_keys_str_mv AT drostrm preclinicalmousemodelsforbrca1associatedbreastcancer
AT jonkersj preclinicalmousemodelsforbrca1associatedbreastcancer

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