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Preclinical mouse models for BRCA1-associated breast cancer
A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human B...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778535/ https://www.ncbi.nlm.nih.gov/pubmed/19904273 http://dx.doi.org/10.1038/sj.bjc.6605350 |