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Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study

BACKGROUND: This study investigated the potential clinical utility of circulating free DNA (cfDNA) as a source of BRAF mutation detection in patients enrolled into a phase II study of AZD6244, a specific MEK1/2 inhibitor, in patients with advanced melanoma. METHODS: BRAF mutations were detected usin...

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Detalles Bibliográficos
Autores principales:	Board, R E, Ellison, G, Orr, M C M, Kemsley, K R, McWalter, G, Blockley, L Y, Dearden, S P, Morris, C, Ranson, M, Cantarini, M V, Dive, C, Hughes, A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778539/ https://www.ncbi.nlm.nih.gov/pubmed/19861964 http://dx.doi.org/10.1038/sj.bjc.6605371

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