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Humanised IgG1 antibody variants targeting membrane-bound carcinoembryonic antigen by antibody-dependent cellular cytotoxicity and phagocytosis

BACKGROUND: The effect of glycoengineering a membrane specific anti-carcinoembryonic antigen (CEA) (this paper uses the original term CEA for the formally designated CEACAM5) antibody (PR1A3) on its ability to enhance killing of colorectal cancer (CRC) cell lines by human immune effector cells was a...

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Detalles Bibliográficos
Autores principales:	Ashraf, S Q, Umana, P, Mössner, E, Ntouroupi, T, Brünker, P, Schmidt, C, Wilding, J L, Mortensen, N J, Bodmer, W F
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778542/ https://www.ncbi.nlm.nih.gov/pubmed/19904275 http://dx.doi.org/10.1038/sj.bjc.6605355

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