Cargando…

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer

BACKGROUND: Delta-like ligand 4 (Dll4) is a Notch ligand that is upregulated by hypoxia and vascular endothelial growth factor-A (VEGF-A) and is reported to have a role in tumor angiogenesis. Evidence from xenograft studies suggests that inhibiting Dll4–Notch signalling may overcome resistance to an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jubb, A M, Turley, H, Moeller, H C, Steers, G, Han, C, Li, J-L, Leek, R, Tan, E Y, Singh, B, Mortensen, N J, Noguera-Troise, I, Pezzella, F, Gatter, K C, Thurston, G, Fox, S B, Harris, A L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778546/ https://www.ncbi.nlm.nih.gov/pubmed/19844231 http://dx.doi.org/10.1038/sj.bjc.6605368

Ejemplares similares

Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer
por: Kato, T, et al.
Publicado: (2007)

Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression
por: Couvelard, A, et al.
Publicado: (2005)

A quantitative analysis of lymphatic vessels in human breast cancer, based on LYVE-1 immunoreactivity
por: Kato, T, et al.
Publicado: (2005)

DLL4 expression is a prognostic marker and may predict gemcitabine benefit in resected pancreatic cancer
por: Drouillard, A, et al.
Publicado: (2016)

CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding
por: Adam, P J, et al.
Publicado: (2006)

Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth
por: Oon, Chern Ein, et al.
Publicado: (2017)

Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions
por: Adighibe, O, et al.
Publicado: (2006)

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
por: Kuhnert, Frank, et al.
Publicado: (2011)

Endothelial Delta-like 4 (DLL4) promotes renal cell carcinoma hematogenous metastasis
por: Huang, Qing Bo, et al.
Publicado: (2014)

The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy?
por: Brzozowa, Marlena, et al.
Publicado: (2013)

Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer
por: Tan, Ern Yu, et al.
Publicado: (2007)

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia
por: Koukourakis, M I, et al.
Publicado: (2010)

Bone Marrow-Derived Endothelial Progenitors Expressing Delta-Like 4 (Dll4) Regulate Tumor Angiogenesis
por: Real, Carla, et al.
Publicado: (2011)

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer.
por: Leek, R. D., et al.
Publicado: (1994)

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)
por: Jovanovic, Vuk P, et al.
Publicado: (2013)

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo
por: Preuße, Kristina, et al.
Publicado: (2015)

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
por: Tveriakhina, Lena, et al.
Publicado: (2018)

High Delta-Like Ligand 4 (DLL4) Is Correlated With Peritumoral Brain Edema and Predicts Poor Prognosis in Primary Glioblastoma
por: Qiu, Xian-xin, et al.
Publicado: (2014)

PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells
por: Chien, W, et al.
Publicado: (2013)

Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
por: Giatromanolaki, A, et al.
Publicado: (2001)

Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis
por: Rasheed, S, et al.
Publicado: (2009)

Radiation induced COX-2 expression and mutagenesis at non-targeted lung tissues of gpt delta transgenic mice
por: Chai, Y, et al.
Publicado: (2013)

Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro
por: Tiemeijer, L. A., et al.
Publicado: (2018)

Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine
por: Shimizu, Hiromichi, et al.
Publicado: (2014)

Protocol for validation of the 4AT, a rapid screening tool for delirium: a multicentre prospective diagnostic test accuracy study
por: Shenkin, Susan D, et al.
Publicado: (2018)

The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis
por: Gee, H E, et al.
Publicado: (2011)

Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer
por: Andersen, C L, et al.
Publicado: (2009)

Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis
por: Chen, C, et al.
Publicado: (2014)

Clinical implications of DLL4 expression in gastric cancer
por: Ishigami, Sumiya, et al.
Publicado: (2013)

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC
por: Voorneveld, P W, et al.
Publicado: (2015)

The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers
por: Chakrabarti, J, et al.
Publicado: (2004)

Influence of preanalytical variables on performance of delta-like protein 3 (DLL3) predictive immunohistochemistry
por: Radonic, Teodora, et al.
Publicado: (2020)

Vascular phenotypes in primary non-small cell lung carcinomas and matched brain metastases
por: Jubb, A M, et al.
Publicado: (2011)

Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer
por: Schaefer, C, et al.
Publicado: (2005)

Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours
por: Rijlaarsdam, M A, et al.
Publicado: (2011)

HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation
por: Jung, C, et al.
Publicado: (2005)

RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas
por: Deb, S, et al.
Publicado: (2014)

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
por: Geffers, Insa, et al.
Publicado: (2007)

The status of CDKN2A alpha (p16(INK4A)) and beta (p14(ARF)) transcripts in thyroid tumour progression
por: Ferru, A, et al.
Publicado: (2006)

Therapeutic promise and challenges of targeting DLL4/NOTCH1
por: Yan, Minhong
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_reaet1ecss9kn81l9k84r279o9