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Activation and clinical significance of the unfolded protein response in breast cancer

INTRODUCTION: The tumour microenvironment is hypoglycaemic, hypoxic and acidotic. This activates a stress signalling pathway: the unfolded protein response (UPR). The UPR is cytoprotective if the stressor is mild, but may initiate apoptosis if severe. Activation of the UPR in breast carcinoma is ind...

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Detalles Bibliográficos
Autores principales:	Scriven, P, Coulson, S, Haines, R, Balasubramanian, S, Cross, S, Wyld, L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778547/ https://www.ncbi.nlm.nih.gov/pubmed/19861963 http://dx.doi.org/10.1038/sj.bjc.6605365

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