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Formation of Polyglutamine Inclusions in a Wide Range of Non-CNS Tissues in the HdhQ150 Knock-In Mouse Model of Huntington's Disease

BACKGROUND: Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by a CAG repeat expansion in the ubiquitously expressed HD gene resulting in an abnormally long polyglutamine repeat in the huntingtin protein. Polyglutamine inclusions are a hallmark of the neur...

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Detalles Bibliográficos
Autores principales:	Moffitt, Hilary, McPhail, Graham D., Woodman, Ben, Hobbs, Carl, Bates, Gillian P.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778556/ https://www.ncbi.nlm.nih.gov/pubmed/19956633 http://dx.doi.org/10.1371/journal.pone.0008025

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