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Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases

Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as a distinct entity for a very long time, because of lack of distinct clinical features and morphological criteria, it is difficult to diagnose this variant correctly. We herein present the clinical,...

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Autores principales: Sharma, Sunita, Nangia, Anita, Jain Malhotra, Sonal, Narayan, Shashi, Harbhajanka, Aparna, Singh, Sarika
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778566/
https://www.ncbi.nlm.nih.gov/pubmed/19960061
http://dx.doi.org/10.1155/2009/461912
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author Sharma, Sunita
Nangia, Anita
Jain Malhotra, Sonal
Narayan, Shashi
Harbhajanka, Aparna
Singh, Sarika
author_facet Sharma, Sunita
Nangia, Anita
Jain Malhotra, Sonal
Narayan, Shashi
Harbhajanka, Aparna
Singh, Sarika
author_sort Sharma, Sunita
collection PubMed
description Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as a distinct entity for a very long time, because of lack of distinct clinical features and morphological criteria, it is difficult to diagnose this variant correctly. We herein present the clinical, morphological, cytochemical, and immunocytochemical features of five cases of AMKL. Certain morphological features such as presence of abnormal platelet count, giant platelets, and cytoplasmic blebbing in blasts were found to be important pointers towards the diagnosis. However, none of the features were found to be consistent and thus morphological diagnosis has to be confirmed by cytochemistry and immunocytochemistry.
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spelling pubmed-27785662009-12-03 Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases Sharma, Sunita Nangia, Anita Jain Malhotra, Sonal Narayan, Shashi Harbhajanka, Aparna Singh, Sarika Adv Hematol Case Report Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as a distinct entity for a very long time, because of lack of distinct clinical features and morphological criteria, it is difficult to diagnose this variant correctly. We herein present the clinical, morphological, cytochemical, and immunocytochemical features of five cases of AMKL. Certain morphological features such as presence of abnormal platelet count, giant platelets, and cytoplasmic blebbing in blasts were found to be important pointers towards the diagnosis. However, none of the features were found to be consistent and thus morphological diagnosis has to be confirmed by cytochemistry and immunocytochemistry. Hindawi Publishing Corporation 2009 2008-01-28 /pmc/articles/PMC2778566/ /pubmed/19960061 http://dx.doi.org/10.1155/2009/461912 Text en Copyright © 2009 Sunita Sharma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sharma, Sunita
Nangia, Anita
Jain Malhotra, Sonal
Narayan, Shashi
Harbhajanka, Aparna
Singh, Sarika
Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases
title Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases
title_full Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases
title_fullStr Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases
title_full_unstemmed Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases
title_short Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases
title_sort clinico-haematological profile of acute megakaryoblastic leukaemia: report of five cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778566/
https://www.ncbi.nlm.nih.gov/pubmed/19960061
http://dx.doi.org/10.1155/2009/461912
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