The role of SPARC in extracellular matrix assembly

SPARC is a collagen-binding matricellular protein. Expression of SPARC in adult tissues is frequently associated with excessive deposition of collagen and SPARC-null mice fail to generate a robust fibrotic response to a variety of stimuli. This review summarizes recent advancements in the characteri...

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Detalles Bibliográficos
Autor principal: Bradshaw, Amy D.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778582/
https://www.ncbi.nlm.nih.gov/pubmed/19798598
http://dx.doi.org/10.1007/s12079-009-0062-6
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author Bradshaw, Amy D.
author_facet Bradshaw, Amy D.
author_sort Bradshaw, Amy D.
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description SPARC is a collagen-binding matricellular protein. Expression of SPARC in adult tissues is frequently associated with excessive deposition of collagen and SPARC-null mice fail to generate a robust fibrotic response to a variety of stimuli. This review summarizes recent advancements in the characterization of the binding of SPARC to collagens and describes the results of studies that implicate a function for SPARC in the regulation of the assembly of basal lamina and fibrillar collagen in the ECM. Potential cellular mechanisms that underlie SPARC activity in ECM deposition are also explored.
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spelling pubmed-27785822009-11-20 The role of SPARC in extracellular matrix assembly Bradshaw, Amy D. J Cell Commun Signal Research Article SPARC is a collagen-binding matricellular protein. Expression of SPARC in adult tissues is frequently associated with excessive deposition of collagen and SPARC-null mice fail to generate a robust fibrotic response to a variety of stimuli. This review summarizes recent advancements in the characterization of the binding of SPARC to collagens and describes the results of studies that implicate a function for SPARC in the regulation of the assembly of basal lamina and fibrillar collagen in the ECM. Potential cellular mechanisms that underlie SPARC activity in ECM deposition are also explored. Springer Netherlands 2009-10-02 2009-12 /pmc/articles/PMC2778582/ /pubmed/19798598 http://dx.doi.org/10.1007/s12079-009-0062-6 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Research Article
Bradshaw, Amy D.
The role of SPARC in extracellular matrix assembly
title The role of SPARC in extracellular matrix assembly
title_full The role of SPARC in extracellular matrix assembly
title_fullStr The role of SPARC in extracellular matrix assembly
title_full_unstemmed The role of SPARC in extracellular matrix assembly
title_short The role of SPARC in extracellular matrix assembly
title_sort role of sparc in extracellular matrix assembly
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778582/
https://www.ncbi.nlm.nih.gov/pubmed/19798598
http://dx.doi.org/10.1007/s12079-009-0062-6
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