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The role of osteopontin in inflammatory processes

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory dis...

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Detalles Bibliográficos
Autores principales: Lund, Susan Amanda, Giachelli, Cecilia M., Scatena, Marta
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778587/
https://www.ncbi.nlm.nih.gov/pubmed/19798593
http://dx.doi.org/10.1007/s12079-009-0068-0
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author Lund, Susan Amanda
Giachelli, Cecilia M.
Scatena, Marta
author_facet Lund, Susan Amanda
Giachelli, Cecilia M.
Scatena, Marta
author_sort Lund, Susan Amanda
collection PubMed
description Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory diseases. Through interactions with several integrins, OPN mediates cell migration, adhesion, and survival in many cell types. OPN also functions as a Th1 cytokine, promotes cell-mediated immune responses, and plays a role in chronic inflammatory and autoimmune diseases. Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification.
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spelling pubmed-27785872009-11-20 The role of osteopontin in inflammatory processes Lund, Susan Amanda Giachelli, Cecilia M. Scatena, Marta J Cell Commun Signal Research Article Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory diseases. Through interactions with several integrins, OPN mediates cell migration, adhesion, and survival in many cell types. OPN also functions as a Th1 cytokine, promotes cell-mediated immune responses, and plays a role in chronic inflammatory and autoimmune diseases. Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification. Springer Netherlands 2009-10-02 2009-12 /pmc/articles/PMC2778587/ /pubmed/19798593 http://dx.doi.org/10.1007/s12079-009-0068-0 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Research Article
Lund, Susan Amanda
Giachelli, Cecilia M.
Scatena, Marta
The role of osteopontin in inflammatory processes
title The role of osteopontin in inflammatory processes
title_full The role of osteopontin in inflammatory processes
title_fullStr The role of osteopontin in inflammatory processes
title_full_unstemmed The role of osteopontin in inflammatory processes
title_short The role of osteopontin in inflammatory processes
title_sort role of osteopontin in inflammatory processes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778587/
https://www.ncbi.nlm.nih.gov/pubmed/19798593
http://dx.doi.org/10.1007/s12079-009-0068-0
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