Cargando…
The role of osteopontin in inflammatory processes
Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory dis...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778587/ https://www.ncbi.nlm.nih.gov/pubmed/19798593 http://dx.doi.org/10.1007/s12079-009-0068-0 |
_version_ | 1782174271525617664 |
---|---|
author | Lund, Susan Amanda Giachelli, Cecilia M. Scatena, Marta |
author_facet | Lund, Susan Amanda Giachelli, Cecilia M. Scatena, Marta |
author_sort | Lund, Susan Amanda |
collection | PubMed |
description | Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory diseases. Through interactions with several integrins, OPN mediates cell migration, adhesion, and survival in many cell types. OPN also functions as a Th1 cytokine, promotes cell-mediated immune responses, and plays a role in chronic inflammatory and autoimmune diseases. Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification. |
format | Text |
id | pubmed-2778587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-27785872009-11-20 The role of osteopontin in inflammatory processes Lund, Susan Amanda Giachelli, Cecilia M. Scatena, Marta J Cell Commun Signal Research Article Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory diseases. Through interactions with several integrins, OPN mediates cell migration, adhesion, and survival in many cell types. OPN also functions as a Th1 cytokine, promotes cell-mediated immune responses, and plays a role in chronic inflammatory and autoimmune diseases. Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification. Springer Netherlands 2009-10-02 2009-12 /pmc/articles/PMC2778587/ /pubmed/19798593 http://dx.doi.org/10.1007/s12079-009-0068-0 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Research Article Lund, Susan Amanda Giachelli, Cecilia M. Scatena, Marta The role of osteopontin in inflammatory processes |
title | The role of osteopontin in inflammatory processes |
title_full | The role of osteopontin in inflammatory processes |
title_fullStr | The role of osteopontin in inflammatory processes |
title_full_unstemmed | The role of osteopontin in inflammatory processes |
title_short | The role of osteopontin in inflammatory processes |
title_sort | role of osteopontin in inflammatory processes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778587/ https://www.ncbi.nlm.nih.gov/pubmed/19798593 http://dx.doi.org/10.1007/s12079-009-0068-0 |
work_keys_str_mv | AT lundsusanamanda theroleofosteopontinininflammatoryprocesses AT giachelliceciliam theroleofosteopontinininflammatoryprocesses AT scatenamarta theroleofosteopontinininflammatoryprocesses AT lundsusanamanda roleofosteopontinininflammatoryprocesses AT giachelliceciliam roleofosteopontinininflammatoryprocesses AT scatenamarta roleofosteopontinininflammatoryprocesses |