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The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming

BACKGROUND: Sarcopenia is a major public health problem in industrialized nations, placing an increasing burden on public healthcare systems because the loss of skeletal muscle mass and strength that characterizes this affection increases the dependence and the risk of injury caused by sudden falls...

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Autores principales: Bidon, Caroline, Lachuer, Joël, Molgó, Jordi, Wierinckx, Anne, de la Porte, Sabine, Pignol, Bernadette, Christen, Yves, Meloni, Rolando, Koenig, Herbert, Biguet, Nicole Faucon, Mallet, Jacques
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778626/
https://www.ncbi.nlm.nih.gov/pubmed/19956636
http://dx.doi.org/10.1371/journal.pone.0007998
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author Bidon, Caroline
Lachuer, Joël
Molgó, Jordi
Wierinckx, Anne
de la Porte, Sabine
Pignol, Bernadette
Christen, Yves
Meloni, Rolando
Koenig, Herbert
Biguet, Nicole Faucon
Mallet, Jacques
author_facet Bidon, Caroline
Lachuer, Joël
Molgó, Jordi
Wierinckx, Anne
de la Porte, Sabine
Pignol, Bernadette
Christen, Yves
Meloni, Rolando
Koenig, Herbert
Biguet, Nicole Faucon
Mallet, Jacques
author_sort Bidon, Caroline
collection PubMed
description BACKGROUND: Sarcopenia is a major public health problem in industrialized nations, placing an increasing burden on public healthcare systems because the loss of skeletal muscle mass and strength that characterizes this affection increases the dependence and the risk of injury caused by sudden falls in elderly people. Albeit exercise and caloric restriction improve sarcopenia-associated decline of the muscular performances, a more suitable and focused pharmacological treatment is still lacking. METHODOLOGY/PRINCIPAL FINDINGS: In order to evaluate such a possible treatment, we investigated the effects of EGb 761, a Ginkgo biloba extract used in chronic age-dependent neurological disorders, on the function of the soleus muscle in aged rats. EGb 761 induced a gain in muscular mass that was associated with an improvement of the muscular performances as assessed by biochemical and electrophysiological tests. DNA microarray analysis shows that these modifications are accompanied by the transcriptional reprogramming of genes related to myogenesis through the TGFβ signaling pathway and to energy production via fatty acids and glucose oxidation. EGb 761 restored a more juvenile gene expression pattern by regenerating the aged muscle and reversing the age-related metabolic shift from lipids to glucose utilization. CONCLUSIONS/SIGNIFICANCE: Thus, EGb 761 may represent a novel treatment for sarcopenia both more manageable and less cumbersome than exercise and caloric restriction.
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spelling pubmed-27786262009-12-03 The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming Bidon, Caroline Lachuer, Joël Molgó, Jordi Wierinckx, Anne de la Porte, Sabine Pignol, Bernadette Christen, Yves Meloni, Rolando Koenig, Herbert Biguet, Nicole Faucon Mallet, Jacques PLoS One Research Article BACKGROUND: Sarcopenia is a major public health problem in industrialized nations, placing an increasing burden on public healthcare systems because the loss of skeletal muscle mass and strength that characterizes this affection increases the dependence and the risk of injury caused by sudden falls in elderly people. Albeit exercise and caloric restriction improve sarcopenia-associated decline of the muscular performances, a more suitable and focused pharmacological treatment is still lacking. METHODOLOGY/PRINCIPAL FINDINGS: In order to evaluate such a possible treatment, we investigated the effects of EGb 761, a Ginkgo biloba extract used in chronic age-dependent neurological disorders, on the function of the soleus muscle in aged rats. EGb 761 induced a gain in muscular mass that was associated with an improvement of the muscular performances as assessed by biochemical and electrophysiological tests. DNA microarray analysis shows that these modifications are accompanied by the transcriptional reprogramming of genes related to myogenesis through the TGFβ signaling pathway and to energy production via fatty acids and glucose oxidation. EGb 761 restored a more juvenile gene expression pattern by regenerating the aged muscle and reversing the age-related metabolic shift from lipids to glucose utilization. CONCLUSIONS/SIGNIFICANCE: Thus, EGb 761 may represent a novel treatment for sarcopenia both more manageable and less cumbersome than exercise and caloric restriction. Public Library of Science 2009-11-24 /pmc/articles/PMC2778626/ /pubmed/19956636 http://dx.doi.org/10.1371/journal.pone.0007998 Text en Bidon et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bidon, Caroline
Lachuer, Joël
Molgó, Jordi
Wierinckx, Anne
de la Porte, Sabine
Pignol, Bernadette
Christen, Yves
Meloni, Rolando
Koenig, Herbert
Biguet, Nicole Faucon
Mallet, Jacques
The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming
title The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming
title_full The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming
title_fullStr The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming
title_full_unstemmed The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming
title_short The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming
title_sort extract of ginkgo biloba egb 761 reactivates a juvenile profile in the skeletal muscle of sarcopenic rats by transcriptional reprogramming
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778626/
https://www.ncbi.nlm.nih.gov/pubmed/19956636
http://dx.doi.org/10.1371/journal.pone.0007998
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