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Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography
Determining how flow affects the concentration of the adenine nucleotides ATP and ADP at the vascular endothelial cell (EC) surface is essential for understanding flow-induced mobilization of intracellular calcium. Previously, mathematical models were formulated to describe the ATP/ADP concentration...
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Formato: | Texto |
Lenguaje: | English |
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Springer US
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778776/ https://www.ncbi.nlm.nih.gov/pubmed/19763828 http://dx.doi.org/10.1007/s10439-009-9793-z |
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author | Choi, Hyo Won Barakat, Abdul I. |
author_facet | Choi, Hyo Won Barakat, Abdul I. |
author_sort | Choi, Hyo Won |
collection | PubMed |
description | Determining how flow affects the concentration of the adenine nucleotides ATP and ADP at the vascular endothelial cell (EC) surface is essential for understanding flow-induced mobilization of intracellular calcium. Previously, mathematical models were formulated to describe the ATP/ADP concentration at the EC surface; however, all previous models assumed the endothelium to be flat. In the present study we investigate the effect of surface undulations on ATP/ADP concentration at the EC surface. The results demonstrate that under certain geometric and flow conditions, the ATP + ADP concentration at the EC surface is considerably lower for a wavy cell surface than for a flat surface. Because ECs in regions of disturbed arterial flow are expected to have larger undulations than cells in non-disturbed flow zones, our findings suggest that ECs in regions of flow disturbance would exhibit lower ATP + ADP concentrations at their surfaces, which may lead to impaired calcium signaling. If validated experimentally, the present results may contribute to our understanding of endothelial cell dysfunction observed in regions of disturbed flow. |
format | Text |
id | pubmed-2778776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-27787762009-11-20 Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography Choi, Hyo Won Barakat, Abdul I. Ann Biomed Eng Article Determining how flow affects the concentration of the adenine nucleotides ATP and ADP at the vascular endothelial cell (EC) surface is essential for understanding flow-induced mobilization of intracellular calcium. Previously, mathematical models were formulated to describe the ATP/ADP concentration at the EC surface; however, all previous models assumed the endothelium to be flat. In the present study we investigate the effect of surface undulations on ATP/ADP concentration at the EC surface. The results demonstrate that under certain geometric and flow conditions, the ATP + ADP concentration at the EC surface is considerably lower for a wavy cell surface than for a flat surface. Because ECs in regions of disturbed arterial flow are expected to have larger undulations than cells in non-disturbed flow zones, our findings suggest that ECs in regions of flow disturbance would exhibit lower ATP + ADP concentrations at their surfaces, which may lead to impaired calcium signaling. If validated experimentally, the present results may contribute to our understanding of endothelial cell dysfunction observed in regions of disturbed flow. Springer US 2009-09-18 2009 /pmc/articles/PMC2778776/ /pubmed/19763828 http://dx.doi.org/10.1007/s10439-009-9793-z Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Choi, Hyo Won Barakat, Abdul I. Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography |
title | Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography |
title_full | Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography |
title_fullStr | Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography |
title_full_unstemmed | Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography |
title_short | Modulation of ATP/ADP Concentration at the Endothelial Cell Surface by Flow: Effect of Cell Topography |
title_sort | modulation of atp/adp concentration at the endothelial cell surface by flow: effect of cell topography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778776/ https://www.ncbi.nlm.nih.gov/pubmed/19763828 http://dx.doi.org/10.1007/s10439-009-9793-z |
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