Mechanism of cellular rejection in transplantation

The explosion of new discoveries in the field of immunology has provided new insights into mechanisms that promote an immune response directed against a transplanted organ. Central to the allograft response are T lymphocytes. This review summarizes the current literature on allorecognition, costimul...

Descripción completa

Detalles Bibliográficos
Autor principal: Ingulli, Elizabeth
Formato: Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2010
Materias:
Educational Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778785/
https://www.ncbi.nlm.nih.gov/pubmed/21476231
http://dx.doi.org/10.1007/s00467-008-1020-x
_version_ 1782174300654010368
author Ingulli, Elizabeth
author_facet Ingulli, Elizabeth
author_sort Ingulli, Elizabeth
collection PubMed
description The explosion of new discoveries in the field of immunology has provided new insights into mechanisms that promote an immune response directed against a transplanted organ. Central to the allograft response are T lymphocytes. This review summarizes the current literature on allorecognition, costimulation, memory T cells, T cell migration, and their role in both acute and chronic graft destruction. An in depth understanding of the cellular mechanisms that result in both acute and chronic allograft rejection will provide new strategies and targeted therapeutics capable of inducing long-lasting, allograft-specific tolerance.
format Text
id pubmed-2778785
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-27787852009-11-20 Mechanism of cellular rejection in transplantation Ingulli, Elizabeth Pediatr Nephrol Educational Review The explosion of new discoveries in the field of immunology has provided new insights into mechanisms that promote an immune response directed against a transplanted organ. Central to the allograft response are T lymphocytes. This review summarizes the current literature on allorecognition, costimulation, memory T cells, T cell migration, and their role in both acute and chronic graft destruction. An in depth understanding of the cellular mechanisms that result in both acute and chronic allograft rejection will provide new strategies and targeted therapeutics capable of inducing long-lasting, allograft-specific tolerance. Springer Berlin Heidelberg 2010-01-01 2010 /pmc/articles/PMC2778785/ /pubmed/21476231 http://dx.doi.org/10.1007/s00467-008-1020-x Text en © IPNA 2008 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Educational Review
Ingulli, Elizabeth
Mechanism of cellular rejection in transplantation
title Mechanism of cellular rejection in transplantation
title_full Mechanism of cellular rejection in transplantation
title_fullStr Mechanism of cellular rejection in transplantation
title_full_unstemmed Mechanism of cellular rejection in transplantation
title_short Mechanism of cellular rejection in transplantation
title_sort mechanism of cellular rejection in transplantation
topic Educational Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778785/
https://www.ncbi.nlm.nih.gov/pubmed/21476231
http://dx.doi.org/10.1007/s00467-008-1020-x
work_keys_str_mv AT ingullielizabeth mechanismofcellularrejectionintransplantation

Ejemplares similares