Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia

The Philadelphia (Ph(1)) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex variant...

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Autores principales: Valencia, Ana, Cervera, José, Such, Esperanza, Barragán, Eva, Bolufer, Pascual, Fuster, Oscar, Collado, Rosa, Martínez, Jesús, Sanz, Miguel A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778832/
https://www.ncbi.nlm.nih.gov/pubmed/19946422
http://dx.doi.org/10.1155/2009/187125
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author Valencia, Ana
Cervera, José
Such, Esperanza
Barragán, Eva
Bolufer, Pascual
Fuster, Oscar
Collado, Rosa
Martínez, Jesús
Sanz, Miguel A.
author_facet Valencia, Ana
Cervera, José
Such, Esperanza
Barragán, Eva
Bolufer, Pascual
Fuster, Oscar
Collado, Rosa
Martínez, Jesús
Sanz, Miguel A.
author_sort Valencia, Ana
collection PubMed
description The Philadelphia (Ph(1)) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex variants of this translocation, involving various breakpoints in addition to 9q34 and 22q11. We report five CML cases carrying variant Ph translocations involving both chromosomes 9 and 22 as well as chromosomes 3, 5, 7, 8, or 10. G-banding showed a reciprocal three-way translocation involving 3q21, 5q31, 7q32, 8q24, and 10q22 bands. BCR-ABL fusion signal on der(22) was found in all of the cases by FISH.
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spelling pubmed-27788322009-11-24 Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia Valencia, Ana Cervera, José Such, Esperanza Barragán, Eva Bolufer, Pascual Fuster, Oscar Collado, Rosa Martínez, Jesús Sanz, Miguel A. Adv Hematol Clinical Study The Philadelphia (Ph(1)) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex variants of this translocation, involving various breakpoints in addition to 9q34 and 22q11. We report five CML cases carrying variant Ph translocations involving both chromosomes 9 and 22 as well as chromosomes 3, 5, 7, 8, or 10. G-banding showed a reciprocal three-way translocation involving 3q21, 5q31, 7q32, 8q24, and 10q22 bands. BCR-ABL fusion signal on der(22) was found in all of the cases by FISH. Hindawi Publishing Corporation 2009 2009-07-28 /pmc/articles/PMC2778832/ /pubmed/19946422 http://dx.doi.org/10.1155/2009/187125 Text en Copyright © 2009 Ana Valencia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Valencia, Ana
Cervera, José
Such, Esperanza
Barragán, Eva
Bolufer, Pascual
Fuster, Oscar
Collado, Rosa
Martínez, Jesús
Sanz, Miguel A.
Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
title Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
title_full Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
title_fullStr Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
title_full_unstemmed Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
title_short Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
title_sort complex variant t(9;22) chromosome translocations in five cases of chronic myeloid leukemia
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778832/
https://www.ncbi.nlm.nih.gov/pubmed/19946422
http://dx.doi.org/10.1155/2009/187125
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