C-Terminal Mutants of Apolipoprotein L-I Efficiently Kill Both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T. brucei subspecies rhodesiense and gambiense resist this lytic activity and can infect humans, causing sleeping sickness. In the case...

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Detalles Bibliográficos
Autores principales: Lecordier, Laurence, Vanhollebeke, Benoit, Poelvoorde, Philippe, Tebabi, Patricia, Paturiaux-Hanocq, Françoise, Andris, Fabienne, Lins, Laurence, Pays, Etienne
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778949/
https://www.ncbi.nlm.nih.gov/pubmed/19997494
http://dx.doi.org/10.1371/journal.ppat.1000685

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