Cargando…

Harnessing gene expression to identify the genetic basis of drug resistance

The advent of cost-effective genotyping and sequencing methods have recently made it possible to ask questions that address the genetic basis of phenotypic diversity and how natural variants interact with the environment. We developed Camelot (CAusal Modelling with Expression Linkage for cOmplex Tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Bo-Juen, Causton, Helen C, Mancenido, Denesy, Goddard, Noel L, Perlstein, Ethan O, Pe'er, Dana
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779083/ https://www.ncbi.nlm.nih.gov/pubmed/19888205 http://dx.doi.org/10.1038/msb.2009.69

Ejemplares similares

Context Sensitive Modeling of Cancer Drug Sensitivity
por: Chen, Bo-Juen, et al.
Publicado: (2015)

Broadening horizons: holistic viewpoints from the Biology of Genomes
por: Carr, Ambrose, et al.
Publicado: (2014)

Inference of modules associated to eQTLs
por: Kreimer, Anat, et al.
Publicado: (2012)

Harnessing Natural Sequence Variation to Dissect Posttranscriptional Regulatory Networks in Yeast
por: Fazlollahi, Mina, et al.
Publicado: (2014)

Harnessing the Genetic Basis of Sorghum Biomass-Related Traits to Facilitate Bioenergy Applications
por: Yang, Lin, et al.
Publicado: (2023)

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity
por: Brown, Chrysothemis C., et al.
Publicado: (2019)

Pathology of eyelid tumors
por: Pe’er, Jacob
Publicado: (2016)

Harnessing RNAi nanomedicine for precision therapy
por: Peer, Dan
Publicado: (2014)

Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology
por: Chu, Tinyi, et al.
Publicado: (2022)

JISTIC: Identification of Significant Targets in Cancer
por: Sanchez-Garcia, Felix, et al.
Publicado: (2010)

Learning time-varying information flow from single-cell epithelial to mesenchymal transition data
por: Krishnaswamy, Smita, et al.
Publicado: (2018)

DisGeNET-RDF: harnessing the innovative power of the Semantic Web to explore the genetic basis of diseases
por: Queralt-Rosinach, Núria, et al.
Publicado: (2016)

Variants in exons and in transcription factors affect gene expression in trans
por: Kreimer, Anat, et al.
Publicado: (2013)

Co-regulated Transcripts Associated to Cooperating eSNPs Define Bi-fan Motifs in Human Gene Networks
por: Kreimer, Anat, et al.
Publicado: (2014)

Ultrafast genome-wide scan for SNP–SNP interactions in common complex disease
por: Prabhu, Snehit, et al.
Publicado: (2012)

Choroidal Metastasis of Adenocarcinoma of the Lung Presenting as Pigmented Choroidal Tumor
por: Frenkel, Shahar, et al.
Publicado: (2012)

Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies
por: Palmer, Cameron, et al.
Publicado: (2017)

Bias Characterization in Probabilistic Genotype Data and Improved Signal Detection with Multiple Imputation
por: Palmer, Cameron, et al.
Publicado: (2016)

Media Exposure to Armed Conflict: Dispositional Optimism and Self-Mastery Moderate Distress and Post-Traumatic Symptoms among Adolescents
por: Pe’er, Ayelet, et al.
Publicado: (2022)

Anatomy of the Crowd4Discovery crowdfunding campaign
por: Perlstein, Ethan O
Publicado: (2013)

The covariance environment defines cellular niches for spatial inference
por: Haviv, Doron, et al.
Publicado: (2023)

Wishbone identifies bifurcating developmental trajectories from single-cell data
por: Setty, Manu, et al.
Publicado: (2016)

Inference of historical migration rates via haplotype sharing
por: Palamara, Pier Francesco, et al.
Publicado: (2013)

Environmental controls on butterfly occurrence and species richness in Israel: The importance of temperature over rainfall
por: Comay, Orr, et al.
Publicado: (2021)

Genotype-Environment Interactions Reveal Causal Pathways That Mediate Genetic Effects on Phenotype
por: Gagneur, Julien, et al.
Publicado: (2013)

Characterization of cell fate probabilities in single-cell data with Palantir
por: Setty, Manu, et al.
Publicado: (2019)

A Hidden Markov Model for Copy Number Variant prediction from whole genome resequencing data
por: Shen, Yufeng, et al.
Publicado: (2011)

Previous trauma exposure and self-mastery as moderators of psychiatric effects of home isolation during the Covid-19 pandemic: a field study
por: Slone, Michelle, et al.
Publicado: (2022)

MiSDEED: a synthetic data engine for microbiome study power analysis and study design
por: Chlenski, Philippe, et al.
Publicado: (2022)

Prenatal genetic screening and diagnostic testing during the COVID-19 pandemic in the Bronx, NY
por: Rabin-Havt, Sara, et al.
Publicado: (2021)

Identifying the Common Genetic Basis of Antidepressant Response
por: Pain, Oliver, et al.
Publicado: (2021)

Quantifying and Analyzing the Network Basis of Genetic Complexity
por: Thompson, Ethan G., et al.
Publicado: (2012)

Editorial: Harnessing placebo mechanisms
por: Seneviratne, Chamindi, et al.
Publicado: (2022)

The genetic basis of resistance to antimicrobial drugs
Publicado: (2005)

Ten Simple Rules of Live Tweeting at Scientific Conferences
por: Ekins, Sean, et al.
Publicado: (2014)

Using Expression and Genotype to Predict Drug Response in Yeast
por: Ruderfer, Douglas M., et al.
Publicado: (2009)

SARS-CoV2 Infection and the Importance of Potassium Balance
por: Causton, Helen C.
Publicado: (2021)

2-Way k-Means as a Model for Microbiome Samples
por: Jackson, Weston J., et al.
Publicado: (2017)

Torsin ATPases: Harnessing Dynamic Instability for Function
por: Chase, Anna R., et al.
Publicado: (2017)

Correction: Quantifying and Analyzing the Network Basis of Genetic Complexity
por: Thompson, Ethan G., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_jr16q8060kumsaoq08g9039pqm