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Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src

Carcinoembryonic antigen (CEA)–related cell adhesion molecule 1 (CAM1 [CEACAM1]) mediates homophilic cell adhesion and regulates signaling. Although there is evidence that CEACAM1 binds and activates SHP-1, SHP-2, and c-Src, knowledge about the mechanism of transmembrane signaling is lacking. To ana...

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Detalles Bibliográficos
Autores principales:	Müller, Mario M., Klaile, Esther, Vorontsova, Olga, Singer, Bernhard B., Öbrink, Björn
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779222/ https://www.ncbi.nlm.nih.gov/pubmed/19948503 http://dx.doi.org/10.1083/jcb.200904150

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