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Journeys through the Golgi—taking stock in a new era

The Golgi apparatus is essential for protein sorting and transport. Many researchers have long been fascinated with the form and function of this organelle. Yet, despite decades of scrutiny, the mechanisms by which proteins are transported across the Golgi remain controversial. At a recent meeting,...

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Detalles Bibliográficos
Autores principales: Emr, Scott, Glick, Benjamin S., Linstedt, Adam D., Lippincott-Schwartz, Jennifer, Luini, Alberto, Malhotra, Vivek, Marsh, Brad J., Nakano, Akihiko, Pfeffer, Suzanne R., Rabouille, Catherine, Rothman, James E., Warren, Graham, Wieland, Felix T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779233/
https://www.ncbi.nlm.nih.gov/pubmed/19948493
http://dx.doi.org/10.1083/jcb.200909011
Descripción
Sumario:The Golgi apparatus is essential for protein sorting and transport. Many researchers have long been fascinated with the form and function of this organelle. Yet, despite decades of scrutiny, the mechanisms by which proteins are transported across the Golgi remain controversial. At a recent meeting, many prominent Golgi researchers assembled to critically evaluate the core issues in the field. This report presents the outcome of their discussions and highlights the key open questions that will help guide the field into a new era.