MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts

Myeloid cell leukemia sequence 1 (MCL-1) and B cell leukemia/lymphoma 2 (BCL-2) are anti-apoptotic proteins in the BCL-2 protein family often expressed in cancer. To compare the function of MCL-1 and BCL-2 in maintaining cancer survival, we constructed complementary mouse leukemia models based on Eμ...

Descripción completa

Detalles Bibliográficos
Autores principales: Brunelle, Joslyn K., Ryan, Jeremy, Yecies, Derek, Opferman, Joseph T., Letai, Anthony
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779245/
https://www.ncbi.nlm.nih.gov/pubmed/19948485
http://dx.doi.org/10.1083/jcb.200904049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779245/
https://www.ncbi.nlm.nih.gov/pubmed/19948485
http://dx.doi.org/10.1083/jcb.200904049

Ejemplares similares