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MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts

Myeloid cell leukemia sequence 1 (MCL-1) and B cell leukemia/lymphoma 2 (BCL-2) are anti-apoptotic proteins in the BCL-2 protein family often expressed in cancer. To compare the function of MCL-1 and BCL-2 in maintaining cancer survival, we constructed complementary mouse leukemia models based on Eμ...

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Detalles Bibliográficos
Autores principales:	Brunelle, Joslyn K., Ryan, Jeremy, Yecies, Derek, Opferman, Joseph T., Letai, Anthony
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779245/ https://www.ncbi.nlm.nih.gov/pubmed/19948485 http://dx.doi.org/10.1083/jcb.200904049

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