From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity

The activity of Raf-1 and Rok-α kinases is regulated by intramolecular binding of the regulatory region to the kinase domain. Autoinhibition is relieved upon binding to the small guanosine triphosphatases Ras and Rho. Downstream of Ras, Raf-1 promotes migration and tumorigenesis by antagonizing Rok-...

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Detalles Bibliográficos
Autores principales: Niault, Théodora, Sobczak, Izabela, Meissl, Katrin, Weitsman, Gregory, Piazzolla, Daniela, Maurer, Gabriele, Kern, Florian, Ehrenreiter, Karin, Hamerl, Matthias, Moarefi, Ismail, Leung, Thomas, Carugo, Oliviero, Ng, Tony, Baccarini, Manuela
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779248/
https://www.ncbi.nlm.nih.gov/pubmed/19948477
http://dx.doi.org/10.1083/jcb.200906178

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