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Gastrointestinal Stromal Tumors in Koreans: It's Incidence and the Clinical, Pathologic and Immunohistochemical Findings

Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63%), fol...

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Autores principales: Kim, Kyoung-Mee, Kang, Dong Wook, Moon, Woo Sung, Park, Jae Bok, Park, Cheol Keun, Sohn, Jin Hee, Jeong, Jin Sook, Cho, Mee-Yon, Jin, So-Young, Choi, Jong Sang, Kang, Dae Young
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779330/
https://www.ncbi.nlm.nih.gov/pubmed/16361808
http://dx.doi.org/10.3346/jkms.2005.20.6.977
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author Kim, Kyoung-Mee
Kang, Dong Wook
Moon, Woo Sung
Park, Jae Bok
Park, Cheol Keun
Sohn, Jin Hee
Jeong, Jin Sook
Cho, Mee-Yon
Jin, So-Young
Choi, Jong Sang
Kang, Dae Young
author_facet Kim, Kyoung-Mee
Kang, Dong Wook
Moon, Woo Sung
Park, Jae Bok
Park, Cheol Keun
Sohn, Jin Hee
Jeong, Jin Sook
Cho, Mee-Yon
Jin, So-Young
Choi, Jong Sang
Kang, Dae Young
author_sort Kim, Kyoung-Mee
collection PubMed
description Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63%), followed by the small intestine (30%), the colorectum (5%), and the esophagus (2%). c-kit expression was found in 93.6% of the cases, while CD34, SMA and S-100 protein was positive in 80.1%, 28.2%, and 20.2%, respectively. c-kit positivity was high in the stomach (94.2%) and small intestine (94.6%), while it was relatively low in the colorectum (85.0%), and esophagus (81.2%). The positivity for CD34 was correlated with the higher risk of GISTs (p=0.04). Follow up of the patients showed that 58 primary GISTs patients died and 20 of these patients were recurrent or metastatic at the time of diagnosis. The pathologic diagnosis to predict the risk of aggressive behavior of GISTs was correlated with the numbers of tumor, clinical stage, epithelioid histologic type, cellularity, cellular atypia, necrosis, and mucosal invasion (p=0.00). GISTs with a poor prognosis were closely related to the clinical stage at presentation, the locations of the tumor, and the ages of the patients.
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spelling pubmed-27793302009-11-20 Gastrointestinal Stromal Tumors in Koreans: It's Incidence and the Clinical, Pathologic and Immunohistochemical Findings Kim, Kyoung-Mee Kang, Dong Wook Moon, Woo Sung Park, Jae Bok Park, Cheol Keun Sohn, Jin Hee Jeong, Jin Sook Cho, Mee-Yon Jin, So-Young Choi, Jong Sang Kang, Dae Young J Korean Med Sci Original Article Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63%), followed by the small intestine (30%), the colorectum (5%), and the esophagus (2%). c-kit expression was found in 93.6% of the cases, while CD34, SMA and S-100 protein was positive in 80.1%, 28.2%, and 20.2%, respectively. c-kit positivity was high in the stomach (94.2%) and small intestine (94.6%), while it was relatively low in the colorectum (85.0%), and esophagus (81.2%). The positivity for CD34 was correlated with the higher risk of GISTs (p=0.04). Follow up of the patients showed that 58 primary GISTs patients died and 20 of these patients were recurrent or metastatic at the time of diagnosis. The pathologic diagnosis to predict the risk of aggressive behavior of GISTs was correlated with the numbers of tumor, clinical stage, epithelioid histologic type, cellularity, cellular atypia, necrosis, and mucosal invasion (p=0.00). GISTs with a poor prognosis were closely related to the clinical stage at presentation, the locations of the tumor, and the ages of the patients. The Korean Academy of Medical Sciences 2005-12 2005-12-31 /pmc/articles/PMC2779330/ /pubmed/16361808 http://dx.doi.org/10.3346/jkms.2005.20.6.977 Text en Copyright © 2005 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Kyoung-Mee
Kang, Dong Wook
Moon, Woo Sung
Park, Jae Bok
Park, Cheol Keun
Sohn, Jin Hee
Jeong, Jin Sook
Cho, Mee-Yon
Jin, So-Young
Choi, Jong Sang
Kang, Dae Young
Gastrointestinal Stromal Tumors in Koreans: It's Incidence and the Clinical, Pathologic and Immunohistochemical Findings
title Gastrointestinal Stromal Tumors in Koreans: It's Incidence and the Clinical, Pathologic and Immunohistochemical Findings
title_full Gastrointestinal Stromal Tumors in Koreans: It's Incidence and the Clinical, Pathologic and Immunohistochemical Findings
title_fullStr Gastrointestinal Stromal Tumors in Koreans: It's Incidence and the Clinical, Pathologic and Immunohistochemical Findings
title_full_unstemmed Gastrointestinal Stromal Tumors in Koreans: It's Incidence and the Clinical, Pathologic and Immunohistochemical Findings
title_short Gastrointestinal Stromal Tumors in Koreans: It's Incidence and the Clinical, Pathologic and Immunohistochemical Findings
title_sort gastrointestinal stromal tumors in koreans: it's incidence and the clinical, pathologic and immunohistochemical findings
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779330/
https://www.ncbi.nlm.nih.gov/pubmed/16361808
http://dx.doi.org/10.3346/jkms.2005.20.6.977
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