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Prognostic Factors in 77 Curative Chest Wall Resections for Isolated Breast Cancer Recurrence
BACKGROUND: Full-thickness chest wall resection (CWR) is the preferred treatment for breast cancer (BC) patients with extensive isolated locoregional recurrence. It remains a challenge to select patients that will benefit most from this treatment. The aim of this study was to define prognostic facto...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779420/ https://www.ncbi.nlm.nih.gov/pubmed/19672659 http://dx.doi.org/10.1245/s10434-009-0662-7 |
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author | van der Pol, Carmen C. van Geel, Albertus N. Menke-Pluymers, Marian B. E. Schmitz, Paul I. M. Lans, Titia E. |
author_facet | van der Pol, Carmen C. van Geel, Albertus N. Menke-Pluymers, Marian B. E. Schmitz, Paul I. M. Lans, Titia E. |
author_sort | van der Pol, Carmen C. |
collection | PubMed |
description | BACKGROUND: Full-thickness chest wall resection (CWR) is the preferred treatment for breast cancer (BC) patients with extensive isolated locoregional recurrence. It remains a challenge to select patients that will benefit most from this treatment. The aim of this study was to define prognostic factors in patients who undergo CWR with curative intent. METHODS: BC patients who underwent a CWR with curative intent for recurrence of disease between 1986 and 2006 were included in this retrospective study. Twenty-two factors were studied in a univariate analyses, and multivariate stepwise Cox regression analyses was performed. RESULTS: Seventy-seven patients were included in this study. The 5-year overall survival was 25%. There was one postoperative death. Univariate analyses showed that three prognostic factors were significantly correlated with OS and disease-free survival: (1) interval between primary treatment and CWR (P = .02 and .004, respectively), (2) chemotherapy for recurrence (P = .05 and .05, respectively), and (3) resection specimen smaller than 150 cm(2) (P = .03 and .009, respectively). An interval lasting >10 years between primary treatment and CWR remained statistically significantly correlated with better overall survival and disease-free survival after multivariate analyses. CONCLUSIONS: CWR is a safe treatment in patients who have isolated extensive BC recurrence. The best survival outcome was seen in patients after a disease-free interval of ≥10 years. Existing data show that adjuvant radiotherapy and adjuvant hormone therapy for estrogen-positive tumors improves overall survival. Neoadjuvant chemotherapy may be considered in individual patients. |
format | Text |
id | pubmed-2779420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-27794202009-11-23 Prognostic Factors in 77 Curative Chest Wall Resections for Isolated Breast Cancer Recurrence van der Pol, Carmen C. van Geel, Albertus N. Menke-Pluymers, Marian B. E. Schmitz, Paul I. M. Lans, Titia E. Ann Surg Oncol Breast Oncology BACKGROUND: Full-thickness chest wall resection (CWR) is the preferred treatment for breast cancer (BC) patients with extensive isolated locoregional recurrence. It remains a challenge to select patients that will benefit most from this treatment. The aim of this study was to define prognostic factors in patients who undergo CWR with curative intent. METHODS: BC patients who underwent a CWR with curative intent for recurrence of disease between 1986 and 2006 were included in this retrospective study. Twenty-two factors were studied in a univariate analyses, and multivariate stepwise Cox regression analyses was performed. RESULTS: Seventy-seven patients were included in this study. The 5-year overall survival was 25%. There was one postoperative death. Univariate analyses showed that three prognostic factors were significantly correlated with OS and disease-free survival: (1) interval between primary treatment and CWR (P = .02 and .004, respectively), (2) chemotherapy for recurrence (P = .05 and .05, respectively), and (3) resection specimen smaller than 150 cm(2) (P = .03 and .009, respectively). An interval lasting >10 years between primary treatment and CWR remained statistically significantly correlated with better overall survival and disease-free survival after multivariate analyses. CONCLUSIONS: CWR is a safe treatment in patients who have isolated extensive BC recurrence. The best survival outcome was seen in patients after a disease-free interval of ≥10 years. Existing data show that adjuvant radiotherapy and adjuvant hormone therapy for estrogen-positive tumors improves overall survival. Neoadjuvant chemotherapy may be considered in individual patients. Springer-Verlag 2009-08-12 2009 /pmc/articles/PMC2779420/ /pubmed/19672659 http://dx.doi.org/10.1245/s10434-009-0662-7 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Breast Oncology van der Pol, Carmen C. van Geel, Albertus N. Menke-Pluymers, Marian B. E. Schmitz, Paul I. M. Lans, Titia E. Prognostic Factors in 77 Curative Chest Wall Resections for Isolated Breast Cancer Recurrence |
title | Prognostic Factors in 77 Curative Chest Wall Resections for Isolated Breast Cancer Recurrence |
title_full | Prognostic Factors in 77 Curative Chest Wall Resections for Isolated Breast Cancer Recurrence |
title_fullStr | Prognostic Factors in 77 Curative Chest Wall Resections for Isolated Breast Cancer Recurrence |
title_full_unstemmed | Prognostic Factors in 77 Curative Chest Wall Resections for Isolated Breast Cancer Recurrence |
title_short | Prognostic Factors in 77 Curative Chest Wall Resections for Isolated Breast Cancer Recurrence |
title_sort | prognostic factors in 77 curative chest wall resections for isolated breast cancer recurrence |
topic | Breast Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779420/ https://www.ncbi.nlm.nih.gov/pubmed/19672659 http://dx.doi.org/10.1245/s10434-009-0662-7 |
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