The E3 Ubiquitin-Ligase Bmi1/Ring1A Controls the Proteasomal Degradation of Top2α Cleavage Complex – A Potentially New Drug Target

BACKGROUND: The topoisomerases Top1, Top2α and Top2β are important molecular targets for antitumor drugs, which specifically poison Top1 or Top2 isomers. While it was previously demonstrated that poisoned Top1 and Top2β are subject to proteasomal degradation, this phenomena was not demonstrated for...

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Detalles Bibliográficos
Autores principales: Alchanati, Iris, Teicher, Carmit, Cohen, Galit, Shemesh, Vivian, Barr, Haim M., Nakache, Philippe, Ben-Avraham, Danny, Idelevich, Anna, Angel, Itzchak, Livnah, Nurit, Tuvia, Shmuel, Reiss, Yuval, Taglicht, Daniel, Erez, Omri
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779455/
https://www.ncbi.nlm.nih.gov/pubmed/19956605
http://dx.doi.org/10.1371/journal.pone.0008104

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