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Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor

WHIM (warts, hypogammaglobulinemia, infections, and myelokatexis) syndrome is a rare immunodeficiency syndrome linked to heterozygous mutations of the chemokine receptor CXCR4 resulting in truncations of its cytoplasmic tail. Leukocytes from patients with WHIM syndrome display impaired CXCR4 interna...

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Detalles Bibliográficos
Autores principales:	McCormick, Peter J., Segarra, Marta, Gasperini, Paola, Gulino, A. Virginia, Tosato, Giovanna
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779657/ https://www.ncbi.nlm.nih.gov/pubmed/19956569 http://dx.doi.org/10.1371/journal.pone.0008102

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