Palladium-catalyzed cross coupling reactions of 4-bromo-6H-1,2-oxazines

A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted reaction of 1,2-oxazine 9c with 1-hexyne prov...

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Detalles Bibliográficos
Autores principales: Zimmer, Reinhold, Schmidt, Elmar, Andrä, Michal, Duhs, Marcel-Antoine, Linder, Igor, Reissig, Hans-Ulrich
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779659/
https://www.ncbi.nlm.nih.gov/pubmed/19936264
http://dx.doi.org/10.3762/bjoc.5.44
Descripción
Sumario:A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted reaction of 1,2-oxazine 9c with 1-hexyne provided alkynyl-substituted pyridine derivative 12 thus demonstrating the potential of this approach for the synthesis of pyridines.

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