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The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study

BACKGROUND: The simultaneous occurrence of cardiovascular disease (CVD), kidney disease, and anaemia is associated with increased morbidity and mortality. In the community setting, little data exists about the risk associated with milder levels of anaemia when it is present concurrently with CVD and...

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Autores principales: Anderson, Jocelyn, Glynn, Liam G, Newell, John, Iglesias, Alberto A, Reddan, Donal, Murphy, Andrew W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779784/
https://www.ncbi.nlm.nih.gov/pubmed/19909540
http://dx.doi.org/10.1186/1471-2261-9-51
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author Anderson, Jocelyn
Glynn, Liam G
Newell, John
Iglesias, Alberto A
Reddan, Donal
Murphy, Andrew W
author_facet Anderson, Jocelyn
Glynn, Liam G
Newell, John
Iglesias, Alberto A
Reddan, Donal
Murphy, Andrew W
author_sort Anderson, Jocelyn
collection PubMed
description BACKGROUND: The simultaneous occurrence of cardiovascular disease (CVD), kidney disease, and anaemia is associated with increased morbidity and mortality. In the community setting, little data exists about the risk associated with milder levels of anaemia when it is present concurrently with CVD and chronic kidney disease (CKD). The aim of this study was to establish the prevalence of CKD and anaemia in patients with CVD in the community and to examine whether the presence of anaemia was associated with increased morbidity and mortality. METHODS: This study was designed as a retrospective cohort study and involved a random sample of 35 general practices in the West of Ireland. A practice-based sample of 1,609 patients with established cardiovascular disease was generated in 2000/2001 and followed for five years. The primary endpoint was death from any cause. Statistical analysis involved using one-way ANOVA and Chi-squared tests for baseline data and Cox proportional-hazards models for mortality data. RESULTS: Of the study sample of 617 patients with blood results, 33% (n = 203) had CKD while 6% (n = 37) had CKD and anaemia. The estimated risk of death from any cause, when compared to patients with cardiovascular disease only, was almost double (HR = 1.98, 95% CI 0.99 to 3.98) for patients with both CVD and CKD and was over 4 times greater (HR = 4.33, 95% CI 1.76 to 10.68) for patients with CVD, CKD and anaemia. CONCLUSION: In patients with cardiovascular disease in the community, chronic kidney disease and anaemia occur commonly. The presence of chronic kidney disease carries an increased mortality risk which increases in an additive way with the addition of anaemia. These results suggest that early primary care diagnosis and management of this high risk group may be worthwhile.
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spelling pubmed-27797842009-11-20 The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study Anderson, Jocelyn Glynn, Liam G Newell, John Iglesias, Alberto A Reddan, Donal Murphy, Andrew W BMC Cardiovasc Disord Research article BACKGROUND: The simultaneous occurrence of cardiovascular disease (CVD), kidney disease, and anaemia is associated with increased morbidity and mortality. In the community setting, little data exists about the risk associated with milder levels of anaemia when it is present concurrently with CVD and chronic kidney disease (CKD). The aim of this study was to establish the prevalence of CKD and anaemia in patients with CVD in the community and to examine whether the presence of anaemia was associated with increased morbidity and mortality. METHODS: This study was designed as a retrospective cohort study and involved a random sample of 35 general practices in the West of Ireland. A practice-based sample of 1,609 patients with established cardiovascular disease was generated in 2000/2001 and followed for five years. The primary endpoint was death from any cause. Statistical analysis involved using one-way ANOVA and Chi-squared tests for baseline data and Cox proportional-hazards models for mortality data. RESULTS: Of the study sample of 617 patients with blood results, 33% (n = 203) had CKD while 6% (n = 37) had CKD and anaemia. The estimated risk of death from any cause, when compared to patients with cardiovascular disease only, was almost double (HR = 1.98, 95% CI 0.99 to 3.98) for patients with both CVD and CKD and was over 4 times greater (HR = 4.33, 95% CI 1.76 to 10.68) for patients with CVD, CKD and anaemia. CONCLUSION: In patients with cardiovascular disease in the community, chronic kidney disease and anaemia occur commonly. The presence of chronic kidney disease carries an increased mortality risk which increases in an additive way with the addition of anaemia. These results suggest that early primary care diagnosis and management of this high risk group may be worthwhile. BioMed Central 2009-11-12 /pmc/articles/PMC2779784/ /pubmed/19909540 http://dx.doi.org/10.1186/1471-2261-9-51 Text en Copyright ©2009 Anderson et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Anderson, Jocelyn
Glynn, Liam G
Newell, John
Iglesias, Alberto A
Reddan, Donal
Murphy, Andrew W
The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study
title The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study
title_full The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study
title_fullStr The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study
title_full_unstemmed The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study
title_short The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study
title_sort impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779784/
https://www.ncbi.nlm.nih.gov/pubmed/19909540
http://dx.doi.org/10.1186/1471-2261-9-51
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