Epigenetic Silencing in Friedreich Ataxia Is Associated with Depletion of CTCF (CCCTC-Binding Factor) and Antisense Transcription

BACKGROUND: Over 15 inherited diseases are caused by expansion of triplet-repeats. Friedreich ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene. The expanded GAA triplet-repeat results in deficiency of FXN gene transcription, which is rever...

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Detalles Bibliográficos
Autores principales: De Biase, Irene, Chutake, Yogesh K., Rindler, Paul M., Bidichandani, Sanjay I.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780319/
https://www.ncbi.nlm.nih.gov/pubmed/19956589
http://dx.doi.org/10.1371/journal.pone.0007914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780319/
https://www.ncbi.nlm.nih.gov/pubmed/19956589
http://dx.doi.org/10.1371/journal.pone.0007914

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