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Inflammatory bowel disease: past, present, and future

Crohn’s disease and ulcerative colitis, collectively known as the inflammatory bowel diseases (IBD), are largely diseases of the twentieth century, and are associated with the rise of modern, Westernized industrial society. Although the causes of these diseases remain incompletely understood, the pr...

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Detalles Bibliográficos
Autor principal: Sands, Bruce E.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780674/
https://www.ncbi.nlm.nih.gov/pubmed/17322989
http://dx.doi.org/10.1007/s00535-006-1995-7
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author Sands, Bruce E.
author_facet Sands, Bruce E.
author_sort Sands, Bruce E.
collection PubMed
description Crohn’s disease and ulcerative colitis, collectively known as the inflammatory bowel diseases (IBD), are largely diseases of the twentieth century, and are associated with the rise of modern, Westernized industrial society. Although the causes of these diseases remain incompletely understood, the prevailing model is that the intestinal flora drives an unmitigated intestinal immune response and inflammation in the genetically susceptible host. A review of the past and present of these diseases shows that detailed description preceded more fundamental elucidation of the disease processes. Working out the details of disease pathogenesis, in turn, has yielded dividends in more focused and effective therapy for IBD. This article highlights the key descriptions of the past, and the pivotal findings of current studies in disease pathogenesis and its connection to medical therapy. Future directions in the IBD will likely explicate the inhomogeneous causes of these diseases, with implications for individualized therapy.
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spelling pubmed-27806742009-11-23 Inflammatory bowel disease: past, present, and future Sands, Bruce E. J Gastroenterol Review Crohn’s disease and ulcerative colitis, collectively known as the inflammatory bowel diseases (IBD), are largely diseases of the twentieth century, and are associated with the rise of modern, Westernized industrial society. Although the causes of these diseases remain incompletely understood, the prevailing model is that the intestinal flora drives an unmitigated intestinal immune response and inflammation in the genetically susceptible host. A review of the past and present of these diseases shows that detailed description preceded more fundamental elucidation of the disease processes. Working out the details of disease pathogenesis, in turn, has yielded dividends in more focused and effective therapy for IBD. This article highlights the key descriptions of the past, and the pivotal findings of current studies in disease pathogenesis and its connection to medical therapy. Future directions in the IBD will likely explicate the inhomogeneous causes of these diseases, with implications for individualized therapy. Springer-Verlag 2007-02-16 2007-01 /pmc/articles/PMC2780674/ /pubmed/17322989 http://dx.doi.org/10.1007/s00535-006-1995-7 Text en © Springer-Verlag Tokyo 2007
spellingShingle Review
Sands, Bruce E.
Inflammatory bowel disease: past, present, and future
title Inflammatory bowel disease: past, present, and future
title_full Inflammatory bowel disease: past, present, and future
title_fullStr Inflammatory bowel disease: past, present, and future
title_full_unstemmed Inflammatory bowel disease: past, present, and future
title_short Inflammatory bowel disease: past, present, and future
title_sort inflammatory bowel disease: past, present, and future
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780674/
https://www.ncbi.nlm.nih.gov/pubmed/17322989
http://dx.doi.org/10.1007/s00535-006-1995-7
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