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High Antibody Titer against Apical Membrane Antigen-1 Is Required to Protect against Malaria in the Aotus Model

A Plasmodium falciparum 3D7 strain Apical Membrane Antigen-1 (AMA1) vaccine, formulated with AS02(A) adjuvant, slowed parasite growth in a recent Phase 1/2a trial, however sterile protection was not observed. We tested this AS02(A), and a Montanide ISA720 (ISA) formulation of 3D7 AMA1 in Aotus monke...

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Detalles Bibliográficos
Autores principales:	Dutta, Sheetij, Sullivan, JoAnn S., Grady, Katharine K., Haynes, J. David, Komisar, Jack, Batchelor, Adrian H., Soisson, Lorraine, Diggs, Carter L., Heppner, D. Gray, Lanar, David E., Collins, William E., Barnwell, John W.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780715/ https://www.ncbi.nlm.nih.gov/pubmed/19997632 http://dx.doi.org/10.1371/journal.pone.0008138

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