Cargando…

Virus-Induced Autoimmune Diabetes in the LEW.1WR1 Rat Requires Iddm14 and a Genetic Locus Proximal to the Major Histocompatibility Complex

OBJECTIVE: To identify genes that confer susceptibility to autoimmune diabetes following viral infection in the LEW.1WR1 rat. RESEARCH DESIGN AND METHODS: About 2% of LEW.1WR1 rats develop spontaneous autoimmune diabetes. Immunological perturbants including viral infection increase both the frequenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blankenhorn, Elizabeth P., Cort, Laura, Greiner, Dale L., Guberski, Dennis L., Mordes, John P.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780864/ https://www.ncbi.nlm.nih.gov/pubmed/19720792 http://dx.doi.org/10.2337/db09-0387

Ejemplares similares

Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats: Prevention of Diabetes by Maternal Immunization
por: Tirabassi, Rebecca S., et al.
Publicado: (2010)

Autoantigen-Induced Focusing of Vβ13(+) T Cells Precedes Onset of Autoimmune Diabetes in the LEW.1WR1 Rat
por: Eberwine, Ryan A., et al.
Publicado: (2014)

Young Adult LEW.1WR1 Rats Develop Dysregulated Islet Function and Impaired Liver Insulin Responses
por: Wilkerson-Vidal, Quiana C, et al.
Publicado: (2021)

A Variable CD3(+) T-Cell Frequency in Peripheral Blood Lymphocytes Associated with Type 1 Diabetes Mellitus Development in the LEW.1AR1-iddm Rat
por: Arndt, Tanja, et al.
Publicado: (2013)

Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti–T-Cell Receptor Antibody: Vβ13 as a Therapeutic Target and Biomarker
por: Liu, Zhijun, et al.
Publicado: (2012)

T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes
por: Mordes, John P., et al.
Publicado: (2021)

Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats
por: Cort, Laura, et al.
Publicado: (2014)

SAT-LB032 Young Adult LEW.1WR1 Rats Develop Increased Glucose Intolerance on a Moderately Increased Sucrose Diet
por: Collins, Genoah, et al.
Publicado: (2019)

Young Adult LEW.1WR1 Rats, a Model of Liver FAT10 Overexpression, Develop Insulin Resistance and Fatty Liver With Age
por: Wimalarathne, Madushika M, et al.
Publicado: (2021)

THU312 The Type 1 Diabetes Susceptible LEW.1WR1 Rat Develops Insulin Resistance And Severe Non-alcoholic Fatty Liver Disease
por: Tahirah Love-Rutledge, Sharifa, et al.
Publicado: (2023)

Implication of HLA-DMA Alleles in Corsican IDDM
por: Cucchi-Mouillot, P., et al.
Publicado: (1998)

Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-α Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes
por: Baskal, Svetlana, et al.
Publicado: (2022)

Lew Kowarski
Publicado: (1962)

Lew Kowarski
Publicado: (1962)

Lew Kowarski
por: Arsenijevic, D
Publicado: (1969)

Antiretroviral activity of aminothiols, WR2721 and WR1065
por: Poirier, Miriam C, et al.
Publicado: (2006)

Prof. Lew Kowarski
por: CERN PhotoLab
Publicado: (1960)

Festschrift Kowarski (Lew)
por: CERN. Geneva
Publicado: (1980)

Lew Kowarski Memorial
por: CERN PhotoLab
Publicado: (1979)

Lew Kowarski Memorial
por: CERN PhotoLab
Publicado: (1979)

Lew Kowarski Memorial
por: CERN PhotoLab
Publicado: (1979)

Lew Kowarski 1907-1979
por: CERN. Geneva
Publicado: (1980)

Lewes String Theory Workshop
por: Clavelli, Lou, et al.
Publicado: (1986)

Analysis of the IDDM Candidate Gene Prss16 in NOD and NON Mice
por: Cheunsuk, Saijai, et al.
Publicado: (2002)

Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes
por: Mi, Xiaofan, et al.
Publicado: (2011)

Frequency of Wr(a) antigen and anti-Wr(a) in Brazilian blood donors
por: Muniz, Janaína Guilhem, et al.
Publicado: (2015)

Fine mapping of genes within the IDDM8 region in rheumatoid arthritis
por: Hinks, Anne, et al.
Publicado: (2006)

Evaluation of oxidative stress in Insulin Dependent Diabetes Mellitus (IDDM) patients
por: Ramakrishna, Vadde, et al.
Publicado: (2007)

Pierre Auger, Edoardo Amaldi and Lew Kowarski
por: Unknown
Publicado: (1952)

Lewes' Practical Text Book of the Diseases of Women
Publicado: (1890)

Dedicated to the Late Professor Jae-Duk Lew
por: Tark, Kwan Chul, et al.
Publicado: (2023)

Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat
por: Zschemisch, Nils-Holger, et al.
Publicado: (2012)

Radiosensitisation and radioprotection by BSO and WR-2721: the role of oxygenation.
por: Durand, R. E., et al.
Publicado: (1989)

Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes
por: Jörns, Anne, et al.
Publicado: (2020)

Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
por: Cunningham, Timothy J, et al.
Publicado: (2006)

Lewes Workshop on Solitons in Nuclear and Elementary-particle Physics
por: Chodos, Alan, et al.
Publicado: (1984)

Lew Kowarski (centre) and Louis Leprince-Ringuet (right)
por: CERN PhotoLab
Publicado: (1964)

Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat
por: Jörns, Anne, et al.
Publicado: (2020)

Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures()
por: Whalen, Barbara J, et al.
Publicado: (2003)

The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up
por: Åkerblom, H. K.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_uduktkjendef476eaaqsdoqad3