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EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice

OBJECTIVE: In obesity, an increased macrophage infiltration in adipose tissue occurs, contributing to low-grade inflammation and insulin resistance. Epidermal growth factor receptor (EGFR) mediates both chemotaxis and proliferation in monocytes and macrophages. However, the role of EGFR inhibitors i...

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Detalles Bibliográficos
Autores principales:	Prada, Patricia O., Ropelle, Eduardo R., Mourão, Rosa H., de Souza, Claudio T., Pauli, Jose R., Cintra, Dennys E., Schenka, André, Rocco, Silvana A., Rittner, Roberto, Franchini, Kleber G., Vassallo, José, Velloso, Lício A., Carvalheira, José B., Saad, Mario J.A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780887/ https://www.ncbi.nlm.nih.gov/pubmed/19696185 http://dx.doi.org/10.2337/db08-0506

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