Cargando…
Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose
OBJECTIVE: Glucokinase (GCK) and glucose-6-phosphatase catalytic subunit 2 (G6PC2) regulate the glucose-cycling step in pancreatic β-cells and may regulate insulin secretion. GCK rs1799884 and G6PC2 rs560887 have been independently associated with fasting glucose, but their interaction on glucose-in...
Autores principales: | Li, Xia, Shu, Yu-Hsiang, Xiang, Anny H., Trigo, Enrique, Kuusisto, Johanna, Hartiala, Jaana, Swift, Amy J., Kawakubo, Miwa, Stringham, Heather M., Bonnycastle, Lori L., Lawrence, Jean M., Laakso, Markku, Allayee, Hooman, Buchanan, Thomas A., Watanabe, Richard M. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780888/ https://www.ncbi.nlm.nih.gov/pubmed/19741163 http://dx.doi.org/10.2337/db09-0228 |
Ejemplares similares
-
Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion
por: Hu, Cheng, et al.
Publicado: (2010) -
Declining β-Cell Compensation for Insulin Resistance in Hispanic Women With Recent Gestational Diabetes Mellitus: Association with changes in weight, adiponectin, and C-reactive protein
por: Xiang, Anny H., et al.
Publicado: (2010) -
GCK exonic mutations induce abnormal biochemical activities and result in GCK-MODY
por: Dai, Tongtong, et al.
Publicado: (2023) -
Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men
por: Stančáková, Alena, et al.
Publicado: (2009) -
GCK Gene Screening and Association of GCK Variants With Gestational Diabetes in North Indian Population
por: Siddiqui, Samreen, et al.
Publicado: (2018)