Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

OBJECTIVE: Chronic exposure of pancreatic β-cells to saturated free fatty acids (FFAs) causes endoplasmic reticulum (ER) stress and apoptosis and may contribute to β-cell loss in type 2 diabetes. Here, we evaluated the molecular mechanisms involved in the protection of β-cells from lipotoxic ER stre...

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Detalles Bibliográficos
Autores principales: Cunha, Daniel A., Ladrière, Laurence, Ortis, Fernanda, Igoillo-Esteve, Mariana, Gurzov, Esteban N., Lupi, Roberto, Marchetti, Piero, Eizirik, Décio L., Cnop, Miriam
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780890/
https://www.ncbi.nlm.nih.gov/pubmed/19720788
http://dx.doi.org/10.2337/db09-0685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780890/
https://www.ncbi.nlm.nih.gov/pubmed/19720788
http://dx.doi.org/10.2337/db09-0685

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